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Phenolic Constituents with Inhibitory Activity against NFAT Transcription from Desmos chinensis  

Kiem Phan Van (Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology)
Minh Chau Van (Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology)
Huang Hoang Thanh (Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology)
Lee Jung Joon (Korea Research Institute of Bioscience and Biotechnology)
Lee Im Seon (College of Pharmacy, Chungnam National University)
Kim Young Ho (College of Pharmacy, Chungnam National University)
Publication Information
Archives of Pharmacal Research / v.28, no.12, 2005 , pp. 1345-1349 More about this Journal
Abstract
Six phenolic constituents, 2-methoxybenzyl benzoate (1), negletein (2), 2',3'-dihydroxy-4',6'­dimethoxydihydrochalcone (3), 5,6-dihydroxy-7-methoxy-dihydroflavone (4), astilbin (5), and quercitrin (6) were isolated from the methanol extract of the dried leaves of Desmos chinensis. Their structures were elucidated from spectral and chemical data. Of these constituents, compounds 2 ($IC_{50}$: 3.89 $\pm$ 0.39 $\mu$M) and 3 ($IC_{50}$: 9.77 $\pm$ 0.26 $\mu$M) exhibited potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor, and compound 1 ($IC_{50}$: 28.4 $\pm$ 2.62 $\mu$M) exhibited moderate inhibitory activity.
Keywords
Desmos chinensis; NFAT Transcription factor; Phenolic constituents;
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