Browse > Article

Potent in Vitro Anticancer Activity of Metacycloprodigiosin and Undecylprodigiosin from a Sponge-Derived Actinomycete Saccharopolyspora sp. nov.  

Liu, Rui (Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China)
Cui, Cheng-Bin (Beijing Institute of Pharmacology and Toxicology)
Duan, Lin (Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China)
Gu, Qian-Qun (Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China)
Zhu, Wei-Ming (Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China)
Publication Information
Archives of Pharmacal Research / v.28, no.12, 2005 , pp. 1341-1344 More about this Journal
Abstract
Bioassay-guided fractionation of $CHCl_{3}$ extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs - metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL­7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.
Keywords
Mycale plumose; Sponge-derived actinomycete; Saccharopolyspora sp. nov; Metacycloprodigiosin; Undecylprodigiosin; Tripyrrole pigments; Cytotoxicity;
Citations & Related Records

Times Cited By Web Of Science : 23  (Related Records In Web of Science)
Times Cited By SCOPUS : 26
연도 인용수 순위
1 Matsuya, H., Okamoto, M., Ochi, T., Nishikawa, A., Shimizu, S., Kataoka, T., Nagai, K., Wasserman, H. H., and Ohkuma, S., Reversible and potent uncoupling of hog gastric ($H^{+}\;+\;K^{+}$)- ATPase by prodigiosins. Biochem. Pharmacol., 60, 1855- 1863 (2000)   DOI   ScienceOn
2 Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer drug screening. J. Natl. Cancer Inst., 82, 1107-1112 (1990)   DOI   PUBMED
3 Wasserman, H. H., Rodgers, G. C., and Keith, D. D., Metacycloprodigiosin, a tripyrrole pigment from Streptomyces longisporus ruber. J. Am. Chem. Soc., 91, 1263-1264 (1969a)   DOI   PUBMED
4 Spongia, S., Mortellaro, A., Taverna, S., Fornasiero, C., Sheiber, E., A., Erba, E., Colotta, F., Mantovani, A., Isetta, A. M., and Golay, J., Characterization of the new immunosuppressive drug undecylprodigiosin in human lymphocytes: retinoblastoma protein, cyclin-dependent kinase-2, and cyclin-dependent kinase-4 as molecular targets. J. Immunol., 158, 3987-3995 (1997)
5 Ricardo, P. Z., Beatriz, M., Esther, L., and Vanessa, S. C., The prodigiosins, proapoptotic drugs with anticancer properties. Biochem. Pharmacol., 66, 1447-1452 (2003)   DOI   ScienceOn
6 Wasserman, H. H., Keith, D. D., and Rodgers, G. C., The structure of metacycloprodigiosin. Tetrahedron, 32, 1855- 1861 (1976b)   DOI   ScienceOn
7 Furstner, A., Grabowski, J., Lehmann, C. W., Kataoka, T. T., and Nagai, K., Synthesis and biological evaluation of nonylprodigiosin and macrocyclic prodigiosin analogues. Chem. Bio. Chem., 2, 60-68 (2001)   DOI   ScienceOn
8 Nakamura, A., Nagai, K., Ando, K., and Tamura, G., Selective suppression by prodigiosin of the mitogenic response of murine splenocytes. J. Antibiot., 39, 1155-1159 (1986)   DOI
9 Sato, T., Konno, H., Tanaka, Y., Kataoka, T., Nagai, K., Wasserman, H. H., and Ohkuma, S., Prodigiosins as a new group of $H^{+}/Cl^{-}$ symporters that uncouple proton translocators. J. Biol. Chem., 273, 21455-21462 (1998)   DOI   ScienceOn