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Induction of Neurite Outgrowth by (-)-(7R, 8S)-Dihydrodehyd­rodiconiferyl Alcohol from PC12 Cells  

Shin Jung Soo (Research Center for Bioresource and Health, Chungbuk National University)
Kim Yu Mi (Research Center for Bioresource and Health, Chungbuk National University)
Hong Seong Su (College of Pharmacy, Chungbuk National University)
Kang Ho Sang (Department of Silviculture and Restoration Ecology, College of Agriculture and Life Sciences, Seoul National University)
Yang Yoo Jung (Research Center for Bioresource and Health, Chungbuk National University)
Lee Don Koo (Department of Silviculture and Restoration Ecology, College of Agriculture and Life Sciences, Seoul National University)
Hwang Bang Yeon (College of Pharmacy, Chungbuk National University)
Ro Jai Seup (College of Pharmacy, Chungbuk National University)
Lee Myung Koo (Research Center for Bioresource and Health, Chungbuk National University)
Publication Information
Archives of Pharmacal Research / v.28, no.12, 2005 , pp. 1337-1340 More about this Journal
Abstract
A lignan derivative, (-)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol (DHDA), was isolated from Kalopanax septemlobus L. and was observed to have neuritogenic activity. DHDA at 50 $\mu$M caused a marked induction of neurite outgrowth and an enhancement of nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. However, it did not exhibit any neurotrophic action. At 50 $\mu$M, DHDA enhanced NGF-induced neurite-bearing activity. This activity was partially blocked by the mitogen-activated protein kinase (MAPK) inhibitor PD98059 and by GF109203X, a protein kinase C (PKC) inhibitor. These results suggest that DHDA can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.
Keywords
(-)-(7R, 8S)-Dihydrodehydrodiconiferyl alcohol; Kalopanax septemlobus; Neurite outgrowth; PC12 cells;
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1 Connor, B. and Dragunow, M., The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res. Rev., 27, 1-39 (1998)   DOI   ScienceOn
2 Greene, L. A. and Tischler, A. S., Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. U.S.A., 73, 2424-2428 (1976)   DOI   ScienceOn
3 Leprince, P., Bonvoisin, C., Rogister, B., Mazy-Servais, C., and Moonen, G., Protein kinase- and staurosporine-dependent induction of neurite outgrowth and plasminogen activator activity in PC12 cells. Biochem. Pharmacol., 52, 1399-1405 (1996)   DOI   ScienceOn
4 Li, P., Matsunaga, K., Yamamoto, K., Yoshikawa, R., Kawashima, K., and Ohizumi, Y., Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells. Neurosci. Lett., 273, 53-56 (1999)   DOI   ScienceOn
5 Patrick, Jr. C. W., Kukreti, S., and McIntire, L. V., Quantitative effects of peripheral monocytes and nerve growth factor on CNS neural morphometric outgrowth parameters in vitro. Exp. Neurol., 138, 277-285 (1996)   DOI   ScienceOn
6 Tsuji, M., Inanami, O., and Kuwabara, M., Induction of neurite outgrowth in PC12 cells by -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway. J. Biol. Chem., 276, 32779- 32785 (2001)   DOI   ScienceOn
7 Angus, W. G. R. and Contreras, M. L., Aroclor 1254 alters the binding of $^{125}I$-labeled nerve growth factor in PC12 cells. Neurosci. Lett., 191, 23-26 (1995)   DOI   ScienceOn
8 Gysbers, J. W. and Rathbone, M. P., Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells. NeuroReport, 3, 997-1000 (1992)
9 Pradines, A., Magazin, M., Schiltz, P., Le Fur, G., Caput, D., and Ferrara, P., Evidence for nerve growth factor-potentiating activities of the nonpeptidic compound SR 57746A in PC12 cells. J. Neurochem., 64, 1954-1964 (1995)   DOI   ScienceOn
10 Sato-Suzuki, I. and Murota, S., Simvastatin inhibits the division and induces neurite-like outgrowth in PC 12 cells. Neurosci. Lett., 220, 21-24 (1996)   DOI   ScienceOn
11 Li, D. W., Lee, E. B., Kang, S. S., Hyun, J. E., and Whang, W. K., Activity-guided isolation of saponins from Kalopanax pictus with anti-inflammatory activity. Chem. Pharm. Bull., 50, 900-903 (2002)   DOI   ScienceOn
12 Sano, M. and Kitajima, S., Activation of mitogen-activated protein kinases is not required for the extension of neurites from PC12D Cells triggered by nerve growth factor. Brain Res., 785, 299-308 (1998)   DOI   ScienceOn
13 Hirao, T., Tsuge, N., Imai, S., Shin-Ya, K., and Seto, H., Nerfilin, a novel microbial metabolite inducing neurite outgrowth of PC12 cells. J. Antibiotics, 48, 1494-1496 (1995)   DOI
14 Middlemiss, P. J., Glasky, A. J., Rathbone, M. P., Werstuik, E., Hindley, S., and Gysbers, J., AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells. Neurosci. Lett., 199, 131-134 (1995)   DOI   ScienceOn
15 Namba, T., The encyclopedia of Wakan-Yaku. Vol. II, Hoikusha Co. Ltd., Tokyo, 154-156 (1980)
16 Hanawa, F., Shiro, M., and Hayashi Y., Heartwood constituents of Betula maximowicziana. Phytochem., 45, 589-595 (1997)   DOI   ScienceOn