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Monoamine Oxidase Inhibitory Constituents from the Fruits of Cudrania tricuspidata  

Han Xiang Hua (College of Pharmacy, Chungbuk National University)
Hong Seong Su (College of Pharmacy, Chungbuk National University)
Hwang Ji Sang (College of Pharmacy, Chungbuk National University)
Jeong Seon Hwa (College of Pharmacy, Chungbuk National University)
Hwang Ji Hye (College of Pharmacy, Chungbuk National University)
Lee Min Hee (College of Pharmacy, Chungbuk National University)
Lee Myung Koo (College of Pharmacy, Chungbuk National University, Research Center for Bioresource and Health, Chungbuk National University)
Lee Dongho (Korea Research Institute of Bioscience and Biotechnology)
Ro Jai Seup (College of Pharmacy, Chungbuk National University)
Hwang Bang Yeon (College of Pharmacy, Chungbuk National University)
Publication Information
Archives of Pharmacal Research / v.28, no.12, 2005 , pp. 1324-1327 More about this Journal
Abstract
A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4'-O-methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with $IC_{50}$ values of 19.4, 23.9, and 25.8 $\mu$M, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B ($IC_{50}$ 0.8 $\mu$M) than MAO-A ($IC_{50}$ >800 $\mu$M). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.
Keywords
Cudrania tricuspidata; Moraceae; Prenylated isoflavone; Gancaonin A; Monoamine oxidase inhibitor;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 10  (Related Records In Web of Science)
Times Cited By SCOPUS : 7
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