Adiponectin Induces Growth Arrest and Apoptosis of MDA-MB231 Breast Cancer Cell
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Kang Jee Hyun
(Department of Family Medicine, College of Medicine, Konyang University)
Lee Yoon Young (Department of Family Medicine, College of Medicine, Korea University) Yu Byung Yeon (Department of Family Medicine, College of Medicine, Konyang University) Yang Beom-Seok (Biomedical Center, KIST) Cho Kyung-Hwan (Department of Family Medicine, College of Medicine, Korea University) Yoon Do Kyoung (Department of Family Medicine, College of Medicine, Korea University) Roh Yong Kyun (Department of Family Medicine, College of Medicine, Hallym University) |
1 | Brakenhielm, E., Veitonmaki, N., Cao, R., Kihara, S., Matsuzawa, Y., Zhivotovsky, B., Funahashi, T., and Cao, Y., Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc. Nat. Acad. Sci. U.S.A., 101, 2476-2481 (2004) DOI |
2 | Dal Maso, L., Augustin, L. S., Karalis, A., Talamini, R., Franceschi, S., Trichopoulos, D., Mantzoros, C. S., and La Vecchia, C., Circulating adiponectin and endometrial cancer risk. J. Clin. Endocrinol. Metab., 89, 1160-1163 (2004) DOI ScienceOn |
3 | Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., Yamashita, S., Funahashi, T., and Matsuzawa, Y., Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation, 100, 2473-2476 (1999) DOI ScienceOn |
4 | Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., and Tataranni, P. A., Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J. Clin. Endocrinol. Metab., 86, 1930-1935 (2001) DOI ScienceOn |
5 | Yamauchi ,T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki, T., Uchida, S., Takekawa, S., Waki, H., Tsuno, N. H., Shibata, Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K., Kitamura, T., Shimizu, T., Nagai, R., and Kadowaki, T., Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature, 423, 762-769 (2003) DOI ScienceOn |
6 | Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., Eto, K., Akanuma, Y., Froguel, P., Foufelle, F., Ferre, P., Carling, D., Kimura, S., Nagai, R., Kahn, B. B., and Kadowaki, T., Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med., 8, 1288-1295 (2002) DOI ScienceOn |
7 | Goktas, S., Yilmaz, M. I., Caglar, K., Sonmez, A., Kilic, S., and Bedir, S., Prostate cancer and adiponectin. Urology, 65, 1168-1172 (2005) DOI ScienceOn |
8 | Okamoto, Y., Kihara, S., Ouchi, N., Nishida, M., Arita, Y., Kumada, M., Ohashi, K., Sakai, N., Shimomura, I., Kobayashi, H., Terasaka, N., Inaba, T., Funahashi, T., and Matsuzawa, Y., Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation, 106, 2767-2770 (2002) DOI ScienceOn |
9 | Miyoshi, Y., Funahashi, T., Kihara, S., Taguchi, T., Tamaki, Y., Matsuzawa, Y., and Noguchi, S., Association of serum adiponectin levels with breast cancer risk. Clin. Cancer Res., 9, 5699-5704 (2003) |
10 | Calle, E. E., Rodriguez, C., Walker-Thurmond, K., and Thun, M. J., Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N. Engl. J. Med., 348, 1625-1638 (2003) DOI ScienceOn |
11 | Scherer, P. E., Williams, S., Fogliano, M., Baldini, G., and Lodish, H. F., A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem., 270, 26746-26749 (1995) DOI ScienceOn |
12 | Hu, E., Liang, P., and Spiegelman, B. M., AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem., 271, 10697-10703 (1996) DOI ScienceOn |
13 | Fruebis, J., Tsao, T. S., Javorschi, S., Ebbets-Reed, D., Erickson, M. R., Yen, F. T., Bihain, B. E., and Lodish, H. F., Proteolytic cleavage product of 30-kDa adipocyte complementrelated protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Nat. Acad. Sci. U.S.A., 98, 2005-2010 (2001) DOI PUBMED ScienceOn |
14 | Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama- Kasaoka, N., Ezaki, O., Akanuma, Y., Gavrilova, O., Vinson, C., Reitman, M. L., Kagechika, H., Shudo, K., Yoda, M., Nakano, Y., Tobe, K., Nagai, R., Kimura, S., Tomita, M., Froguel, P., and Kadowaki, T., The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med., 7, 941-946 (2001) DOI ScienceOn |
15 | Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., Kuriyama, H., Nishida, M., Yamashita, S., Okubo, K., Matsubara, K., Muraguchi, M., Ohmoto, Y., Funahashi, T., and Matsuzawa Y., Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun., 257, 79-83 (1999) DOI ScienceOn |
16 | Rose, D. P., Komninou, D., and Stephenson, G. D., Obesity, adipocytokines, and insulin resistance in breast cancer. Obes. Rev., 5, 153-165 (2004) DOI ScienceOn |
17 | Trujillo, M. E. and Scherer, P. E., Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J. Intern. Med., 257, 167-175 (2005) DOI ScienceOn |
18 | Kumada, M., Kihara, S., Ouchi, N., Kobayashi, H., Okamoto, Y., Ohashi, K., Maeda, K., Nagaretani, H., Kishida, K., Maeda, N., Nagasawa, A., Funahashi, T., and Matsuzawa, Y., Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation, 109, 2046-2049 (2004) DOI ScienceOn |
19 | Waki, H., Yamauchi, T., Kamon, J., Kita, S., Ito, Y., Hada, Y., Uchida, S., Tsuchida, A., Takekawa, S., and Kadowaki, T., Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology, 146, 790-796 (2005) DOI ScienceOn |
20 | Ishikawa, M., Kitayama, J., Kazama, S., Hiramatsu, T., Hatano, K., and Nagawa, H., Plasma adiponectin and gastric cancer. Clin. Cancer Res., 11, 466-472 (2005) |
21 | Mantzoros, C., Petridou, E., Dessypris, N., Chavelas, C., Dalamaga, M., Alexe, D. M., Papadiamantis, Y., Markopoulos, C., Spanos, E., Chrousos, G., and Trichopoulos, D., Adiponectin and breast cancer risk. J. Clin. Endocrinol. Metab., 89, 1102-1107 (2004) DOI ScienceOn |
22 | Fantuzzi, G., Adipose tissue, adipokines, and inflammation. J. Allergy. Clin. Immunol., 115, 911-919 (2005) DOI ScienceOn |
23 | Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., and Matsubara, K., cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem. Biophys. Res. Commun., 221, 286-296 (1996) DOI ScienceOn |
24 | Matsuzawa, Y., Funahashi, T., and Nakamura, T., Molecular, mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann. N. Y. Acad. Sci., 892, 146-154 (1999) DOI PUBMED |
25 | Petridou, E., Mantzoros, C., Dessypris, N., Koukoulomatis, P., Addy, C., Voulgaris, Z., Chrousos, G., and Trichopoulos, D., Plasma adiponectin concentrations in relation to endometrial cancer: a case-control study in Greece. J. Clin. Endocrinol. Metab., 88, 993-997 (2003) DOI ScienceOn |
26 | Wolf, A. M., Wolf, D., Rumpold, H., Enrich, B., and Tilg, H., Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem. Biophys. Res. Commun., 323, 630-635 (2004) DOI ScienceOn |
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