Browse > Article

Antibacterial and Antitumor Macrolides from Streptomyces sp. Is9131  

Zhao Pei-Ji (The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science)
Fan Li-Ming (The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science)
Li Guo-Hong (Laboratory for Conservation and Utilization of Bio-resource, Yunnan University)
Zhu Na (The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science)
Shen Yue-Mao (The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science)
Publication Information
Archives of Pharmacal Research / v.28, no.11, 2005 , pp. 1228-1232 More about this Journal
Abstract
Four compounds, including two novel macrolides, were isolated from an endophyte Streptomyces sp. Is9131 of Maytenus hookeri. Spectral data indicated that these compounds were dimeric dinactin (1), dimeric nonactin (2), cyclo-homononactic acid (3), and cyclo-nonactic acid (4). Bioassay results showed that dimeric dinactin had strong antineoplastic activity and antibacterial activity.
Keywords
Macrolide; Streptomyces sp. Is9131; Antineoplastic activity; Antibacterial activity;
Citations & Related Records

Times Cited By Web Of Science : 18  (Related Records In Web of Science)
Times Cited By SCOPUS : 17
연도 인용수 순위
1 Bartlett, P. A., Meadows, J. D., and Ottow, E., Enantiodivergent syntheses of (+)- and (-)-nonactic acid and the total synthesis of nonactin. J. Am. Chem. Soc., 106, 5304-5311 (1984)   DOI
2 Martyn, J. E. and Nigel, D. P., Synthesis and evaluation of a desigend inhibitor for nonacctin biosynthesis in S. Griseus Ethh a7796. Bioorg. Med. chem. Lett., 7, 2187-2192 (1997)   DOI   ScienceOn
3 Prikrylova, V., Beran, M., Sedmera, P., and Jizba, J., Isolation of nonactic acids from streptomyces griseus fermentation broth by thin-layer and high-performance liquid chromatography. Folia Microbiol., 39, 191-196 (1994)   DOI   ScienceOn
4 Suwanborirux, K., Chang, C. -J., Spiut, R. W., and Cassady, J. M., Ansamitocin P-3, a maytansinoid, from Claopodium crispifolium and Anomodon attenuatus or associated actinomycetes. Experientia, 46, 117-120 (1990)   DOI   PUBMED   ScienceOn
5 Kupchan, S. M., Komoda, Y., Branfman, A. R., Sneden, A. T., Court, W. A., Thomas, G. J., Hintz, H. J. P., Smith, R. M., Karim, A., Howie, G. A., Verma, A. K., Nagao, Y., Dailey, R. G., Zimmerly, V. A., and Sumner, W. C., The maytansinoids, isolation, structural elucidation, and chemical interrelation of novel ansa macrolides. J. Org. Chem., 42, 2349-2357 (1977)   DOI   PUBMED
6 Reider, P. J. and Roland, D. M.. 'Maytansinoids' in 'The Alkaloids', Vol. XXIIII. Academic Press Inc., pp. 71-156, (1984)
7 I-Egashide, E., Asai, M., Ootsu, K., Tanida, S., Kozai, Y., Hasegawa, T., Kishi, T., Sugino, Y., and Yoneda, M., Ansamitocin, a group of novel maytansinoid antibiotics with antitumor properties from Nocardia. Nature, 270, 17-22 (1977)   DOI   PUBMED   ScienceOn
8 Sakai, K., Ichzkawa, T., Yamada, K., Yamashita, M., Tanimoto, M., Hikita, A., Ijuin, Y., and Kondo, K., Antitumor Principles in Mosses: the first isolation and identification of maytansinoids, including a novel 15-methoxyansamitocin P-3. J. Nat. Prod., 51, 845-850 (1988)   DOI   PUBMED   ScienceOn
9 Liu, C. -N., Tadayoni, B. M., Bourret, L. A., Mattocks, K. M., Derr, S. M., Widdison, W. C., Kedersha, N. L., Ariniello, P. D., Goldmacher, V. S., Lambert, J. M., Blattler, W. A., and Chari, R. V. J., Eradication of large colon tumor xenografts by targeted delivery of maytansinoids. Proc. Natl. Acad. Sci., 93, 8618-8623 (1996)   DOI   ScienceOn
10 Stadler, M., Bauch, F., Henkel, T., Muhlbauer, A., Muller, H., Spaltmann, F., Strobel, G. A. and Long, D. -M., Endophytic microbes embody pharmaceutical potential. ASM News, 5, 263-268 (1998)
11 Tomas, R., Jaroslav, S., Vera, P., Ales, P., and Valery, M. D., Five new derivatives of nonactic and homo-nonactic acids from Streptomyces globisporus. Tetrahedron, 60, 4781–4787 (2004)   DOI   ScienceOn
12 Tan, R. -X. and Zou, W. -X., Endophytes: a rich source of functional metabolites. Nat. Prod. Rep., 18, 448-459 (2001)   DOI   ScienceOn
13 Wener, F. F., Michael, R., Stephan, H., and Udo, G., Isolation of dimeric nonactic acid from the nonactin-producing Streptomyces spec. JA 5909-1. J. Basic Microbiol., 36 (4), 235 (1996)   DOI   ScienceOn
14 Espinel-Ingroff, A., White, T., and Pfaller, M. A., Antifungal Agents and Susceptibility Tests, In: Manual of Clinical Microbiology, 7th Edn. (Murray PR ed.), American Society for Microbiology, Washington DC, pp. 1640-1652, (1999)
15 Coghlan, A., Antibodies deliver killer blow to cancer. New Scientist, 20, (1996)