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Cytotoxic Constituents from the Whole Plant of Corydalis pallida  

Kim Hyang Rim (College of Pharmacy, Ewha Womans University)
Min Hye-Young (College of Pharmacy, Ewha Womans University)
Jeong Yeon Hee (College of Pharmacy, Ewha Womans University)
Lee Sang Kook (College of Pharmacy, Ewha Womans University)
Lee Nam Sook (College of Natural Sciences, Ewha Womans University)
Seo Eun-Kyoung (College of Pharmacy, Ewha Womans University)
Publication Information
Archives of Pharmacal Research / v.28, no.11, 2005 , pp. 1224-1227 More about this Journal
Abstract
Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with $IC_{50}$ values of 3.2 and 3.4 $\mu$g/mL, respectively. N­trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.
Keywords
Corydalis pallida; Papaveraceae; Berberine; N-trans-Feruloylmethoxytyramine; N-trans-Feruloyltyramine, Cytotoxicity;
Citations & Related Records

Times Cited By Web Of Science : 6  (Related Records In Web of Science)
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