Browse > Article

Pulsatilla Saponin D: the Antitumor Principle from Pulsatilla koreana  

Kim, Yong (SB Pharmaceutical Co. LTD)
Bang, Seong-Cheol (SB Pharmaceutical Co. LTD)
Lee, Ji-Hyun (SB Pharmaceutical Co. LTD)
Ahn, Byung-Zun (SB Pharmaceutical Co. LTD)
Publication Information
Archives of Pharmacal Research / v.27, no.9, 2004 , pp. 915-918 More about this Journal
Abstract
By bioassay-guided separation, an already known saponin, Pulsatilla saponin D was isolated from the root of Pulsatilla koreana Nakai as a antitumor component when evaluated by in vivo antitumor activity as well as in vitro cytotoxic activity test. It showed potent inhibition rate of tumor growth (IR, 82％) at the dose of 6.4 mg/kg on the BDF1 mice bearing LLC cells.
Keywords
Pulsatilla saponin D; Antitumor activity;
Citations & Related Records

Times Cited By Web Of Science : 5  (Related Records In Web of Science)
Times Cited By SCOPUS : 6
연도 인용수 순위
1 Campbell, W. E., Cragg, G. M. L., and Powrie, A. H., Anemonin, protoanemonin and ranunculin from Knowltonia capensis. Phytochemistry, 18, 323-324 (1979)   DOI   ScienceOn
2 Martin, M. L., San Roman, L., and Dominguez, A., In vitro activity of protoanemonin, an antifungal agent. Planta Med., 56, 66-69 (1990)   DOI   ScienceOn
3 Ye, W. C., Ou, B. X., Ji, N. N., Zhao, S. X., Ye, T., Anthony, M. K., and Paul, S., Patensin, a saponin from Pulsatilla patens var. multifida. Phytochemistry, 39 (4), 937-939 (1995)   DOI   ScienceOn
4 Kang, S. S., Saponins from the root of Pulsatilla koreana. Arch. Pharm. Res., 12, 42-47 (1989)   DOI   ScienceOn
5 Yoshihiro M., Akihito Y., Minpei K., Tomoki A., and Yutaka S., Triterpene saponins and lignans from the root Pulsatilla chinensis and their cytotoxic activity against HL-60 cells. J. Nat. Prod., 62, 1279-1283 (1999)   DOI   ScienceOn
6 Kim, Y., Kim, S. B., You, Y. J., and Ahn, B. Z., Deoxypodophyllotoxin; The cytotoxic and antiangiogenic component from Pulsatilla koreana. Planta Med., 68, 268-271 (2002)   DOI   ScienceOn
7 Kim, S. Y. and Kim, S. B., Anti-tumor effects of extracts of Pulsatilla koreana ($SB-31^{\circledR}$) in vitro. J. Kor. Cancer Assoc., 26 (6), 959-963 (1994)
8 Teruhiro U, Jiro S, Yoshikazu S, Kumio A, and Yuji Y, Antitumor activity of a novel podophylotoxin derivatives (TOP53) against lung cancer and lung matastatic cancer. Cancer Res., 56, 2809-2814 (1996)   PUBMED
9 Viqar U. A., Spectroscopic data of saponins. CRC Press, 1469 (2000)
10 Kim, Y., You, Y., J., Bang, S. C., Lee, C. W., Kim, H. M., and Ahn, B. Z., In vivo, antitumor activity of $SB31^{\circledR}$ injection. Phytother. Res. (2004, submitted)
11 Bae, K. H., The medicinal plants of Korea. Kyo-Hak Press, 139 (1999)
12 Li, R. Z. and Ji, X. J., The cytotoxicity and action mechanism of Ranunculin in vitro. Yao Hsueh Hsueh Pao, 28, 326-331 (1993)
13 Skehan P, Storeng R., Scudiero D., Monks A., McMahon J., Vistica D., Warren J. T., Bokesh H., Kenney S., and Boyd M. R., Feasibility of a highly-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl. Cancer Inst., 82, 1107-1112 (1990)   DOI   PUBMED