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Antiinflammatory Activity of Hyperin from Acanthopanax chiisanensis Roots  

Lee, Sang-Hyun (College of Pharmacy, Seoul National University, Natural Products Research Institute, Seoul National University)
Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University, Natural Products Research Center, Korea Institute of Science and Tech-nology)
Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University, Seokwon Life Science Research Institute, World Sea Green Co. Ltd.)
Yamada, Masateru (Graduate School of Pharmaceutical Sciences, Tohoku University)
Kim, Bak-Kwang (College of Pharmacy, Seoul National University)
Ohuchi, Kazuo (Graduate School of Pharmaceutical Sciences, Tohoku University)
Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University, Seokwon Life Science Research Institute, World Sea Green Co. Ltd.)
Publication Information
Archives of Pharmacal Research / v.27, no.6, 2004 , pp. 628-632 More about this Journal
Abstract
The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited a significant inhibition of prostaglandin E$_2$ (PGE$_2$）production in rat peritoneal macrophages stimulated by the protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate （TPA）. Hyperin was isolated as an active principle from the ethyl acetate fraction. It sup-pressed not only $PGE_2$ production but also nitric oxide （NO） production in vitro in a concentration dependent manner. their $IC_{50}$, being 24.3 and $32.9{\;}{\mu}M$, respectively. Hyperin also caused a significant inhibition of increase in acetic acid-induced vascular permeability in mice in vivo.
Keywords
Acanthopanax chiisanensis; Araliaceae; Hyperin; Anti-inflammatory activity;
Citations & Related Records

Times Cited By Web Of Science : 10  (Related Records In Web of Science)
Times Cited By SCOPUS : 13
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