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Antioxidant Properties of Flavone-6(4')-Carboxaldehyde Oxime Ether Derivatives  

Gulgun, Ayhan-Kilcigil (Faculty of Pharmacy, Ankara University)
Coban, Tulay (Department of Pharmaceutical Chemistry, Department of Toxicology)
Tuncbilek, Meral (Faculty of Pharmacy, Ankara University)
Benay, Can-Eke (Department of Pharmaceutical Chemistry, Department of Toxicology)
Oya, Bozda-Dundar (Faculty of Pharmacy, Ankara University)
Ertan, Rahmiye (Faculty of Pharmacy, Ankara University)
Iscan, Mumtaz (Department of Pharmaceutical Chemistry, Department of Toxicology)
Publication Information
Archives of Pharmacal Research / v.27, no.6, 2004 , pp. 610-614 More about this Journal
Abstract
The in vitro antioxidant properties of some flavone-6(4)-carboxaldehyde oxime ether deriva-tives (Ia-f, lIa-f） were determined by their effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP） levels by measuring the formation of 2-thiobarbituric acid reactive substances. The free radical scavenging properties of the compounds were also examined in vitro by determining their capacity to scavenge superoxide anions and interact with the stable free radical 2, 2-diphenyl-1-picrylhydrazyl (DPPH). The most active compounds, lib (Flavone-4＇-carboxaldehyde-O-ethyl oxime） and Id (Flavone-6-carboxaldehyde-O-［2-(1-pyrolidino） ethyl］ oxime）, caused 98 and 79％ inhibition of superoxide anion production and DPPH stable free radical at $10^{-3}{\;}M$, respectively.
Keywords
Flavone; Oxime ether; Lipid peroxidation; Superoxide dismutase; DPPH; Antioxidant;
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