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5-Arylidene-2(5H)-Furanone Derivatives: Synthesis and Structure-Activity Relationship for Cytotoxicity  

Bang, Seong-Cheol (College of Pharmacy, Chungnam National University)
Kim, Yong (College of Pharmacy, Chungnam National University)
Yun, Mi-Young (Laboratory f Pathology, College of Oriental Medicine, Daejeon University)
Ahn, Byung-Zun (College of Pharmacy, Chungnam National University)
Publication Information
Archives of Pharmacal Research / v.27, no.5, 2004 , pp. 485-494 More about this Journal
Abstract
Thirty-eight 5-arylidene-2(5H)-furanone derivatives possessing halo-, methoxy-, oxo-, dioxo-, and thiophenyl groups as well as anthraquinone and naphthquinone moieties were synthesized, and their cytotoxicity was evaluated against various cancer cell lines. The introduction of halogen atoms or nitro group at aromatic ring of 5-arylidene-2(5H)-furanone was shown to increase the cytotoxicity with 5-(3-nitrobenzylidene )-2(5H)-furanone (21) being the most potent. Among anthracenyl or naphthalenyl derivatives, (E)-5-[2-(1 ,4-dimethoxy-9, 10-dioxo) anthracenyl]-2(5H)-furanone (34) showed the most potent cytotoxic activity.
Keywords
5-Aryline-2(5H)-furnaone; Synthesis; Cytotoxicity;
Citations & Related Records

Times Cited By Web Of Science : 5  (Related Records In Web of Science)
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