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Synthesis and Cytotoxic Activity of 1-(1-Benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones  

Sang-Hun Jung (College of Pharmacy, Chungnam National University)
Hui-Soon Lee (College of Pharmacy, Chungnam National University)
Nam-Soo Kim (College of Pharmacy, Chungnam National University)
Hwan-Mook Kim (Korea Research Institute of Bioscience and Biotechnolog)
Moonsun Lee (Research Laboratories, Dong-Wha Pharm, Ind. Co. Lt)
Dong-Rack Choi (Research Laboratories, Dong-Wha Pharm, Ind. Co. Lt)
Jung-Ah Lee (Research Laboratories, Dong-Wha Pharm, Ind. Co. Lt)
Yong-Ho Chung (Research Laboratories, Dong-Wha Pharm, Ind. Co. Lt)
Eun-Yi Moon (Research Laboratories, Dong-Wha Pharm, Ind. Co. Ltd)
Publication Information
Archives of Pharmacal Research / v.27, no.5, 2004 , pp. 478-484 More about this Journal
Abstract
The novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 2 shows highly potent and broad cytotoxicities. Their cytotoxicities against human lung carcinoma A549, human chronic myelogenous leukemia K562, and human ovarian adenocarcinoma SK-OV-3 are compatible with doxorubicin. Compound 2p (1-[(4-aminobenzoyl)indoline-5-sulfonyl])-4-phenyl-4,5-dihydroimidazolone) exhibits a cytotoxicity that is far more potent than doxorubicin and also exhibits highly effective antitumour activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
Keywords
1-( 1-Benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones; Cytotoxicity; Substituent′s effect;
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