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Synthesis and Biological Evaluation of New Thiazolopyrimidines  

Makarem-Said (Department of Organic Chemistry, Faculty of Pharmacy, Cairo University)
Khaled-Abouzid (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain-Shams University)
Ashraf-Mouneer (Department of Organic Chemistry, Faculty of Pharmacy, Cairo University)
Ali-Ahmedy (Department of Microbiology, Faculty of Pharmacy, Cairo University)
Osman, Abdel-Moneim (Pharmacology Unit, NCI, Cairo University)
Publication Information
Archives of Pharmacal Research / v.27, no.5, 2004 , pp. 471-477 More about this Journal
Abstract
In this study, a series of 4-amino-5-cyano-3-substituted-2,3-dihydrothiazol-2-thiones (1a-c), as well as their triazolo and triazinopyrimidine derivatives such as 8-substituted-3-benzyl-5-meth-ylthiazolo[5,4-e][1,2,4] triazolo[1,5-c]pyrimidin-2-thiones (4-6, 10) and 3-benzyl-5-methyl thiazolo[5,4-e]pyrimidino[3,4-b][1,2,4]triazin-2-thiones (7a-b) were prepared as potential antimicrobial and antitumor agents. Some of the tested compounds showed promising antimicrobial activity and non of them showed any appreciable antitumor activity.
Keywords
Thiazolopyrimidines; Antimicorbial activity; Antitumor activity;
Citations & Related Records

Times Cited By Web Of Science : 9  (Related Records In Web of Science)
Times Cited By SCOPUS : 6
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