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CoMFA and CoMSIA 3D QSAR Studies on Pimarane Cyclooxygenase-2 (COX-2) Inhibitors

Lee, Kwang-Ok (College of Pharmacy, Seoul National University)
Park, Hyun-Ju (College of Pharmacy, Sungkyunkwan University)
Kim, Young-Ho (College of Pharmacy, Chungnam University)
Seo, Seung-Yong (College of Pharmacy, Seoul National University)
Lee, Yong-Sil (College of Pharmacy, Seoul National University)
Moon, Sung-Hyun (College of Pharmacy, Seoul National University)
Kim, Nam-Joong (College of Pharmacy, Seoul National University)
Park, Nam-Song (College of Pharmacy, Seoul National University)
Suh, Young-Ger (College of Pharmacy, Seoul National University)

Publication Information

Archives of Pharmacal Research / v.27, no.5, 2004 , pp. 467-470 More about this Journal

Abstract

Comparative molecular field analysis and comparative molecular similarity indices analysis were performed on twenty five analogues of pimarane COX-2 inhibitor to optimize their cyclooxygenase-2 (COX-2) selective anti-inflammatory activities.

Keywords

3D QSAR; Pimarane diterpenoids; COX-2 inhibitors;

Citations & Related Records

Times Cited By Web Of Science : 2 (Related Records In Web of Science)
Times Cited By SCOPUS : 1

Reference
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