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Crystal Forms of Ketorolac  

Sohn, Young-Taek (College of Pharmacy, Duksung Women′s University)
Seo, Hyun-Ok (College of Pharmacy, Duksung Women′s University)
Publication Information
Archives of Pharmacal Research / v.27, no.3, 2004 , pp. 357-360 More about this Journal
Abstract
Four crystal forms of ketorolac have been obtained by recrystallization in organic solvents under variable conditions. Different ketorolac polymorphs and pseudo polymorph were characterized by X-ray powder diffraction crystallography (XRD), Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). In the dissolution studies in water at $37{\pm}0.5^{\circ}C$ four crystal forms showed different patterns. The solubility of Form I were the highest. The solubility decreased in rank order: Form I> Form II > Form III > Form IV. Form land Form III were shown to have a good physical stability at room temperature for 60 days. However, Form II is converted to Form III and Form IV is converted to Form I after 60 days storage. Therefore, these observations indicate that crystalline polymorphism for ketorolac is readily inter-convertible and the relationship may have to taken into consideration in the formulation of the drug.
Keywords
Ketorolac; Crystalline polymorphism; X-ray powder crystallography; Differential scanning calorimetry; Thermogravimetric analysis;
Citations & Related Records

Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 3
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