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Synthesis and Biological Activities of 8-Arylflavones  

Dao, Tran-Thanh (College of Pharmacy, Kangwon National University)
Kim, Soo-Bae (College of Pharmacy, Kangwon National University)
Sin, Kwan-Seong (College of Pharmacy, Kangwon National University)
Kim, Sang-Hee (College of Pharmacy, Seoul National University)
Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
Park, Hae-Il (College of Pharmacy, Kangwon National University)
Publication Information
Archives of Pharmacal Research / v.27, no.3, 2004 , pp. 278-282 More about this Journal
Abstract
A number of 8-arylflavones have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of $PGE_2$ production. 8-Arylflavones were obtained from commercially available chrysin via two different synthetic pathways. Most 8-arylflavones exhibited much reduced inhibitory activities against COX-2 catalyzed $PGE_2$ production compared to that of wogonin. Functional group replacement at the 8-position of wogonin from methoxy to aryl group caused loss of inhibitory activity. Our present results imply that the functional group at the 8-position of flavones seems to play very important roles for bioactivity.
Keywords
8-Arylflavones; COX-2; Prostaglandin production inhibition; Anti-inflammatory activity; Suzuki reaction; Carbon-carbon coupling reaction;
Citations & Related Records

Times Cited By Web Of Science : 13  (Related Records In Web of Science)
Times Cited By SCOPUS : 9
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