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Antioxidative Constituents from Lycopus lucidus  

Woo, Eun-Rhan (College of Pharmacy, Chosun University)
Piao, Mei-Shan (College of Pharmacy, Chosun University)
Publication Information
Archives of Pharmacal Research / v.27, no.2, 2004 , pp. 173-176 More about this Journal
Abstract
Three phenolic compounds, rosmarinic acid (1), methyl rosmarinate (2), ethyl rosmarinate (3), and two flavonoids, luteolin (4), luteolin-7-O-$\beta$-D-glucuronide methyl ester (5) were isolated from the aerial part of Lycopus lucidus (Labiatae). Their structures were determined by chemical and spectral analysis. Compounds 1-5 exhibited potent antioxidative activity on the NBT superoxide scavenging assay. The $IC_{50}$ values for compounds 1-5 were 2.59, 1.42, 0.78, 2.83, and 3.05 $\mu\textrm{g}$/mL respectively. In addition, five compounds were isolated from this plant for the first time.
Keywords
Lycopus Iucidus; Antioxidant; NBT superoxide scavenging assay; Ethyl rosmarinate;
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