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Synthesis and Antioxidant Properties of Some Novel Benzimidazole Derivatives on Lipid Peroxidation in the Rat Liver  

Canan Kus (Department of Pharmaceutical Chemistry Ankara University)
Gulgun, Ayhan-Kilcigil (Department of Toxicology, Faculty of Pharmacy, Ankara University)
Eke, Benay-Can (Department of Toxicology, Faculty of Pharmacy, Ankara University)
Mumtaz Iscan (Department of Toxicology, Faculty of Pharmacy, Ankara University)
Publication Information
Archives of Pharmacal Research / v.27, no.2, 2004 , pp. 156-163 More about this Journal
Abstract
Some benzimidazole derivatives namely 1-[(substituted thiocarbamoylhydrazine carbonyl) methyl]-2-phenyl-1 H-benzimidazoles (1a-13a), N-[(2-phenylbenzimidazol-1-yl methyl)-[1,3,4]-thiadiazole-2-yl]-substituted phenyl amines (1b-13b) and 5-(2-phenyl benzimidazol-1-yl-methyl)-4-substituted phenyl-4H-1,2,4-triazole-3-thiones (1c-13c) were synthesized, and their in vitro effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. The most active compound 10a caused an 84％ inhibition of LP at $10^{-3}$ M, which is better than that of butylated hydroxytoluene (BHT) (65％).
Keywords
Thiosemicarbazides; Thiadiazolylmethylbenzimidazoles; Triazolylbenzimidazoles; Antioxidant;
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