Da-125 a New Antitumor Agent, Inhibits Topoisomerase II as Topoisomerase Poison and DNA Intercalator Simultaneously |
Seo, Jin-Wook
(Department of Biotechnology, College of Industrial Science, Chung-Ang University)
Lee, Hak-Sung (Department of Biotechnology, College of Industrial Science, Chung-Ang University) Lee, Min-Jun (Department of Biotechnology, College of Industrial Science, Chung-Ang University) Kim, Mi-Ra (Department of Biotechnology, College of Industrial Science, Chung-Ang University) Shin, Cha-Gyun (Department of Biotechnology, College of Industrial Science, Chung-Ang University) |
1 | Chung, M. G., Lee, S. B., Han, S. S., and Roh, J. K., Reproductive toxicity of DA-125, a new anthracycline anticancer agent: peri- and postnatal study in rats. J. Appl. Pharmacal., 3, 38-46 (1995) |
2 | Snapka, R. M., Powelson, M. A., and Strayer, J. M., Swiveling and decatenation of replicating simian virus 40 genome in vivo. Mol. Cell. Biol., 8, 515-521 (1988) DOI PUBMED |
3 | Tewey, K. M., Chen, G. L., Nelson, E. M., and Liu, L. F., Intercalative antitumor drugs interfere with the breakagereunion reaction of mammalian DNA topoisomerase II. J. Bio. Chem., 59, 9182-9191 (1984a) |
4 | Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D., and Liu, L. F., Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science, 226, 466-469 (1984b) DOI PUBMED |
5 | Wang, J. C., DNA topoisomerase. Annu. Rev. Biochem., 54, 665-697 (1985) DOI PUBMED ScienceOn |
6 | Shin, C.-G., Strayer, J. M., Wani, M. A., and Snapka, R. M., Rapid evaluation of topoisomerase inhibitors: caffeine inhibition of topoisomerases in vivo. Teratogen. Carcinogen. Mutagen., 10, 41-52 (1990) DOI ScienceOn |
7 | Snapka, R. M., Permana, P. A., Marquit, G., and Shin, C.-G., Two-dimensional agarose gel analysis of simian virus 40 DNA replication intermediates. Methods: A companion to methods in enzymology, 3, 73-82 (1991) DOI |
8 | DePamphilis, M. L., Chalifour, L. E., Cherette, M. F., Cusick, M. E., Hay, R. T., Henderson, E. A., Pritchard, C. G., Tack, L.C., Wassarman, P. M., Weaver, D. T., and Wirak, D. O., Papovavirus chromosomesas a model for mammalian DNA replication. In: Cozzarelli, N. R. (Ed). Mechanisms of DNA replication and recombination. Alan R Liss, New York, pp. 423-427 (1983) |
9 | Kang, Y. K., Ryoo, B. Y., Kim, T. Y., Im, Y. H., Kim, B. S., Park, Y. H., and Lee, C. T., A phase II trial of DA-125, a novel anthracycline, in advanced non-small-cell lung cancer. Cancer Chemother. Pharmacol., 44, 518-521 (1999) DOI ScienceOn |
10 | Woyrianoski, J. M., Sigmund, R. D., and Beerman, T. A., Topoisomerase-II mediated lesions in nascent DNA: comparison of the effects of epipodophyllotoxin derivatives VM26 and VP16, and 9-anilinoacridine derivatives, m-AMSA. Biochim. Biophys. Acta., 950, 21-28 (1988) DOI PUBMED ScienceOn |
11 | Liu, L. F, DNA Topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem., 58, 351-375 (1989) DOI PUBMED ScienceOn |
12 | Donehower, R. C., Meyers, C. E., and Chabner, B. A., New developments on the mechanisms of action of antineoplastic drugs. Life Sci., 25, 1-14 (1979) DOI ScienceOn |
13 | Douc-Rasy, S., Kayser, A., and Riou, G. F., Inhibition of the reactions catalyzed by a type topoisomerase and a catenating enzyme of Trypanosoma cruzi by DNA-intercalating drugs. EMBO J., 3, 11-21 (1984) PUBMED |
14 | Fantel, A. G., Greenway, J. C., and Juchan, M. R., The embryotoxicity of adriamycin in rat embroys in vitro. Toxicol. Appl. Pharmacal., 80, 155-165 (1985) DOI ScienceOn |
15 | Baik, N. G., Ahn, B. O., Lee, S. B., Kim, W. B., Yang, J., and Watanabe, T., A study on cardiotoxicity of DA-125, a new anticancer antibiotic. J. Appl. pharmacol., 1, 9-19 (1993) |
16 | Hirt, B., Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol., 26, 365-369 (1967) DOI PUBMED |
17 | Kim, S. G., Sung, M., Kang, K. W., Kim, S. H., Son, M. H., and Kim, W. B., DA-125, a novel antracycline derivative showing high-affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway. Cancer Chemother. Pharmacol., 47, 511-518 (2001) DOI ScienceOn |
18 | Myers, C. E., McGuire, W. P., Liss, R. H., Ifrim, I., Grotzinger, L., and Young, R .C., Adriamycin; the role of lipid peroxidation in cardiac toxicity and tumor response. Science, 197, 165-167 (1977) DOI PUBMED |
19 | Shin, C. G. and Snapka, R. M., Exposure to camptothecin breaks leading and lagging strand simian virus 40 DNA replication forks. Biochem. Biophys. Res. Commun., 168, 135-140 (1990) DOI ScienceOn |
20 | Sundin, O. and Varshavsky, A., Arrest of segregation leads to accumulation of highly interwined catenated dimers: dissection of the final stages of SV40 DNA replication. Cell, 21,103-114 (1980) DOI ScienceOn |
21 | Hong, W. S., Jung, H. Y., Yang, S. K., Kim, H. R., and Min, Y. I., Antitumor activity of DA-125, a novel anthracycline, in human gastric and pulmonary adenocarcinoma cells resistant to adriamycin and cisplatin. Anticancer Res., 17, 3613-3621 (1997) PUBMED |
22 | Snapka, R. M., Topoisomerase inhibitors can selectively interfere with different stages of simian virus 40 DNA replication. Mol. Cell. Biol., 6, 4221-4227 (1986) DOI PUBMED |