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Anti-Allergic Activity of 18$\beta$-Glycyrrhetinic acid-3-O-$\beta$-D-glucuronide  

Park, Hae-Young (Department of Food and Nutrition)
Park, Sung-Hwan (College of Pharmacy, Kyung Hee University)
Yoon, Hae-Kyung (Department of Human Life Science, Kyungwon College)
Han, Myung-Joo (Department of Food and Nutrition)
Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
Publication Information
Archives of Pharmacal Research / v.27, no.1, 2004 , pp. 57-60 More about this Journal
Abstract
Glycyrrhizin (18$\beta$-glycyrrhetinic acid-3-O-$\beta$-D-glucuronopyranosyl-(1$\rightarrow2)-\beta$-D-glucuronide, GL) was transformed to 18$\beta$-glycyrrhetinic acid-3-O-$\beta$-D-glucuronide (GAMG) by Streptococcus LJ-22. The antiallergic activities of GL and GAMG was measured using a RBL cell assay system and contact hypersensitivity model mice. GAMG exhibited anti-allergic activity with $IC_{50}$ values of 0.28 mM. GAMG, which is sweeter than GL, and 18$\beta$-glycyrrhetinic acid, which is a GAMG metabolite by human intestinal bacteria, also inhibited the passive cutaneous anaphylaxis and skin contact inflammation. In conclusion, GAMG may be useful as a new sweet food additive and an anti-allergic agent.
Keywords
18$\beta$-Glycyrrhetinic acid-3-O-$\beta$-D-glucuronide; Glycyrrhizin; Streptococcus LJ-22; Anti-allergic activity;
Citations & Related Records

Times Cited By Web Of Science : 24  (Related Records In Web of Science)
Times Cited By SCOPUS : 20
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