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Acetylcholinesterase Inhibitors from the Twigs off Vaccinium oldhami Miquel  

Lee, Jae-Hyeok (College of Pharmacy, Woosuk University)
Lee, Ki-Taek (College of Pharmacy, Woosuk University)
Yang, Jae-Heon (College of Pharmacy, Woosuk University)
Baek, Nam-In (Department of Life Science, Kyung Hee University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Publication Information
Archives of Pharmacal Research / v.27, no.1, 2004 , pp. 53-56 More about this Journal
Abstract
In the course of finding Korean natural products with acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the twigs of Vaccinium oldhami significantly inhibited AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two compounds, taraxerol (1) and scopoletin (2), as active constituents. These compounds inhibited AChE activity in a dose-dependent manner, and the $IC_{50}$/ values of compounds 1 and 2 were 33.6 (79 $\muM$) and 10.0 (52 $\muM$) $\mu$g/mL, respectively.
Keywords
Vaccinium oldhami; Acetylcholinesterase; Taraxerol; Scopoletin;
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Times Cited By Web Of Science : 20  (Related Records In Web of Science)
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