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Identification of Homoserine Lactone Derivatives Using the Methionine Functionalized Solid Phase Synthesis by Gas Chromatography/Mass Spectrometry  

Moon, Hong-Sik (SK R&D Center)
Publication Information
Archives of Pharmacal Research / v.27, no.1, 2004 , pp. 25-30 More about this Journal
Abstract
Combinatorial homoserine lactone mixtures and individual products were obtained from the methionine-functionalized resin in solid-phase synthesis. The four-step process consisting of a coupling step of an N-Fmoc-L-methionine, deprotection of N-Fmoc group, N-coupling with a carboxylic acid, and cleavage reaction through a polymer supported strategy is described. Gas chromatography-mass selective detector (GC-MSD) techniques provide the most powerful methods for identifying both the combinatorial mixtures and individual products.
Keywords
Combinatorial homoserine lactones; Methionine-functionalized resin; Solid-phase synthesis; GS-MSD;
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Times Cited By Web Of Science : 2  (Related Records In Web of Science)
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