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Synthesis of 2-(4-Hydroxyphenyl)benzofurans and Their Application to $\beta$-Amyloid Aggregation Inhibitor  

Choi, Hong-Dae (Department of Chemistry, Dongeui University)
Seo, Pil-Ja (Department of Chemistry, Dongeui University)
Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
Kang, Byoung-Won (Chemical Biology Institute)
Publication Information
Archives of Pharmacal Research / v.27, no.1, 2004 , pp. 19-24 More about this Journal
Abstract
The facile synthesis of a series of 2-(4-hydroxyphenyl)benzofurans (4a-e) is described. The one-pot reaction of 4-substituted phenols with the chloride 1 in the presence of zinc chloride afforded 3-methylthio-2-(4-acetoxyphenyl)benzofurans (2a-e). The compounds 4a-e were obtained from the hydrolysis of 2a-e followed by the desulfurization of the resulting 3-methylthio-2-(4-hydroxyphenyl)benzofurans (3a-e). 5-Methyl-3-p-toluoyl-2 -[4-(3-diethylaminopropoxy)phenyl]benzofuran (7), a $\beta$-amyloid aggregation inhibitor, was synthesized by three steps starting from 4a.
Keywords
2-(4-Hydroxyphenyl)benzofurans; 3-Methylthio-2-(4-acetoxyphenyl)benzofurans; Zinc ch loride; Desulfurization; 5-Methyl-3-p-toluoyl-2-[4-(3-diethylaminopropoxy)phenyl]benzofuran; $\beta$-Amyloid aggregation inhibitor;
Citations & Related Records

Times Cited By Web Of Science : 4  (Related Records In Web of Science)
Times Cited By SCOPUS : 6
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