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Some Pyridazinone and Phthalazinone Derrivatives and Their Vasodilator Activities  

Seref Demirayak (Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Anadolu)
Ismai Kayagil (Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Anadolu)
Kevser Erol (Dept. of Pharmacology, Faculty of Medicine, University of Osmangazi)
Basar Sirmagul (Dept. of Pharmacology, Faculty of Medicine, University of Osmangazi)
Ahmet Cagri Karaburun (Dept. of Pharmacology, Faculty of Medicine, University of Osmangazi)
Publication Information
Archives of Pharmacal Research / v.27, no.1, 2004 , pp. 13-18 More about this Journal
Abstract
In this study, 6-[( 4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone and 4-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-1(2H)-phthalazinone derivatives were synthesized by reacting 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone or 4-(4-aminophenyl)-1(2H)-phthalazinone compound with different 4-arylidene-2-phenyl-5(4H)-oxazolone derivatives. The vasodilator activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity.
Keywords
Pyridazinone; Phthalazinone; Vasodilator activity;
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