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Crosslinking of $\beta$-Cyclodextrin on Cholesterol Removal from Milk  

Kim, S.H. (Department of Food Science and Technology, Sejong University)
Ahn, J. (Department of Food Science and Technology, Sejong University)
Kwak, H.S. (Department of Food Science and Technology, Sejong University)
Publication Information
Archives of Pharmacal Research / v.27, no.11, 2004 , pp. 1183-1187 More about this Journal
Abstract
This study was designed to develop crosslinking of $\beta$-cyclodextrin ($\beta$-CD), and determine the optimum conditions of different factors (mixing time, mixing temperature, and mixing speed) on cholesterol reduction from milk. Crosslinked $\beta$-CD was prepared with epichlorohydrin. When milk was treated with different conditions, the cholesterol removal rate was in the range of 79.4 to 83.3% with 1 % crosslinked $\beta$-CD addition, which were not significantly different among treatments. After cholesterol removal from milk, the used crosslinked $\beta$-CD was washed for cholesterol dissociation and reused. For recycling study, the cholesterol removal rate in first trial was 81.8%, which was mostly same as that using new crosslinked $\beta$-CD. With five trials repeatedly using the same sample, the mean cholesterol removal rate was 81.2%. The present study indicated that the optimum conditions on cholesterol removal using crosslinked $\beta$-CD were 10 min mixing with 400 rpm speed at $5^{\circ}C$ with about 80% cholesterol removal. In addition, crosslinked $\beta$-CD resulted in the effective recycling efficiency almost 100%.
Keywords
Crosslinked $\beta$-CD; Cholesterol removal; Milk; Recycling;
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Times Cited By Web Of Science : 11  (Related Records In Web of Science)
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1 Fleche, G., Chemical modification and degradation of starch. In Van Beynum, G. M. and Roel, J. A. (Eds). Starch conversion technology. Dekker: New York, NY, USA, pp. 73-99 (1985)
2 Hosney, C., Principles of Cereal Science and Technology, AACC. St Paul, MN, USA (1986)
3 Kwak, H. S., Nam, C. G., and Ahn, J., Low cholesterol Mozzarella cheese obtained from homogenized and $\beta$-cyclodextrin-treated milk. Asian-Aust. J. Anim. Sci., 14, 268-275 (2001)   DOI
4 Makoto, K., Akio, O., and Reijiro, S., Cholesterol removal from animal with cyclodextrin by inclusion. Japan Patent, 4,168,198 (1992)
5 Oakenfull, D. G. and Sihdu, G. S., Cholesterol reduction. International Patent, 91/11114 (1991)
6 Whistler, R. and Daniel, R., Function of polysaccharide. In Food Additives, Dekker: New York, NY, USA, pp. 399-406 (1990)
7 Yen, G. C. and Tsui, L. T., Cholesterol removal from a lard-mixture with $\beta$-cyclodextrin. J. Food Sci., 60, 561-564 (1995)   DOI   ScienceOn
8 Adams, M. L., Sullivan, D. M., Smith, R. L., and Richter, E. F., Evaluation of direct saponification method for determination of cholesterol in meats. J. AOAC., 69, 844-846 (1986)
9 Luallen, E. T., Starch as a functional ingredient. Food Technol., 39, 59-63 (1985)
10 Grundy, S. M., Brheimer, D., Blackburn, H., Brown, W. V., Kwiterovich, P. O., Mattson, F., Schonfeld, G., and Weidman, W. H., Rationale of the diet-heart statement of the American Heart Association Report of the Nutrition Committee. Circulation, 65, 839A-854A (1982)   DOI   PUBMED   ScienceOn
11 Hamerstrand, G. E., Hofreiter, B. T., and Mehltretter, C. L., Determination of the extent of reaction between epichlorohydrin and starch. 37, 519-524 (1959)
12 Nagamoto, S., Cyclodextrin-expanding the development of their functions and applications. Chem. Economy Eng. Rev., 17, 28-34 (1985)
13 Szejtli, J., Chemistry and separation of cyclodextrins. In Cyclodextrins and their inclusion complexes; Akademiai Kiado: Budapest, Hungary, pp 17-43 (1982)
14 Szjetli, J., Cyclodextrin inclusion complexes. In Szejtli, J., (Ed.). Cyclodextrin technology, Kluwer Akademic Publishers: Dordrecht, The Netherlands, Chapter 2, pp 79-17 (1988)
15 Lee, D. K., Ahn, J., and Kwak, H. S., Cholesterol removal from homogenized milk with $\beta$-cyclodextrin. J. Dairy Sci., 82, 2327-2330 (1999)   DOI   PUBMED   ScienceOn
16 Kwak, H. S., Kim, S. H., Kim, J. H., Choi, H. J., and Kang, J. M., Simple immobilization of $\beta$-cyclodextrin to remove cholesterol in milk and recycling. Arch. Pharm. Res., 27, 873-877 (2004)   DOI   ScienceOn
17 Ahn, J. and Kwak, H. S., Optimizing cholesterol removal in cream using $\beta$-cyclodextrin and response surface methodology. J. Food Sci., 64, 629-632 (1999)   DOI   ScienceOn
18 SAS Users Guide, Statistics, Version 5; SAS Institute, Inc.: Cary, NC, USA (1985)
19 Kwak, H. S., Suh, H. M., Ahn. J. and Kwon, H. J., Optimization of $\beta$-cyclodextrin recycling process for cholesterol removal in cream. Asian-Aust. J. Anim. Sci., 14, 548-552 (2001)   DOI
20 Gurr, M. I., Dietary lipids and coronary disease: old evidence, new perspectives and progress. Lipid. Res., 31, 195-243 (1992)   DOI   PUBMED   ScienceOn
21 Lee, J. S., Ustunol, Z., and Smith, D. M., Cholesterol removal from animal with cyclodextrin and derivatives. J. Dairy Sci., 76 (Suppl. 1), 143 (Abst.) (1993)