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Protective Constituents Against Sepsis in Mice from the Root Cortex of Paeonia suffruticosa  

Li, Gao (College of Pharmacy, Yanbian University)
Seo, Chang-Seob (College of Pharmacy, Yeungnam University)
Lee, Kyeung-Seon (College of Pharmacy, Yeungnam University)
Kim, Hyo-Jin (College of Pharmacy, Yeungnam University)
Chang, Hyun-Wook (College of Pharmacy, Yeungnam University)
Jung, Jun-Sub (Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine)
Song, Dong-Keun (Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine)
Son, Jong-Keun (College of Pharmacy, Yeungnam University)
Publication Information
Archives of Pharmacal Research / v.27, no.11, 2004 , pp. 1123-1126 More about this Journal
Abstract
The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoniflorin (5), oxypaeoniflorin (6), apiopaeonoside (7), and methyl 3-hydroxy-4-methoxybenzoate (8). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 17% for the control experiment) and reduced alanine aminotransferase level to be a half of the control value on the sepsis model induced by lipopolysaccharide/D-galactosamine.
Keywords
Paeonia suffruticosa; Sepsis; LPS; D-GaIN; ALT;
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