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Synthesis and Antimicrobial Activity of Certain Novel Quinoxalines  

Refaat, Hanan-M. (Organic Chemistry Department, Faculty of Pharmacy, Cairo University)
Moneer, Ashraf-A. (Organic Chemistry Department, Faculty of Pharmacy, Cairo University)
Khalil, Omneya-M. (Organic Chemistry Department, Faculty of Pharmacy, Cairo University)
Publication Information
Archives of Pharmacal Research / v.27, no.11, 2004 , pp. 1093-1098 More about this Journal
Abstract
In this study, certain 3-methyl-2-[4-(substituted amino carbonyl)anilino] quinoxalines, (2a-d) and (3a-d), were synthesized from the new key compound 2-[4-(ethoxycarbonyl)anilino]-3-methyl quinoxaline (1). In addition, a series of 2-[4-(arylidene hydrazinocarbonyl)anilino]-3-methyl quinoxalines (5a-e), as well as their cyclized oxadiazolinyl derivatives (6a-e), and a series of 2-[4-$N^2$-acylhydrazinocarbonyl)anilino]-3-methyl quinoxalines (7a-d), as well as their cyclized oxadiazolyl derivatives (8a-d) were also prepared. Some of these derivatives were evaluated for antimicrobial activity in vitro. It was found that all the selected compounds exhibit antimicrobial activity and that compound 5b had a broad spectrum of activity.
Keywords
2-[4-(Ethoxycarbonyl) anilino]-3-methylquinoxaline; Oxadiazolyl quinoxalires; Antimicrobial agents;
Citations & Related Records

Times Cited By Web Of Science : 12  (Related Records In Web of Science)
Times Cited By SCOPUS : 17
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