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Synthesis and Study of Antibacterial and Antifungal Activities of Novel 2-[[(Benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles  

Kaplancikli, Zafer-Asim (Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry)
Gulhan, Turan-Zitouni (Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry)
Revial, Gilbert (Laboiratoire de Chimie Organique, CNRS (ESA 7084) ESPCI)
Guven, Kiymet (Anadolu University, Faculty of Science, Department of Biology)
Publication Information
Archives of Pharmacal Research / v.27, no.11, 2004 , pp. 1081-1085 More about this Journal
Abstract
Several 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles derivatives were synthesized by reacting 4-substituted-2-(chloroacetylamino)thiazoles with benzoxazole/benzimidazole-2-thioles in acetone and in the presence of $K_2CO_3$. The chemical structures of the compounds were elucidated by IR, $^1H-NMR$, and $FAB^{+}-MS$ spectral data. Their antimicrobial activities against Micrococcus luteus (NRLL B-4375), Bacillus cereus (NRRL B-3711), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (NRRL B-4420), Staphylococcus aureus (NRRL B-767), Escherichia coli (NRRL B-3704), Candida albicans and Candida globrata (isolates obtained from Osmangazi Uni. Fac.of Medicine) were investigated and in this investigation, a significant level of activity was illustrated.
Keywords
Thiazole; Benzoxazole; Benzimidazole; Antimicrobial activity;
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