Browse > Article

Triterpenoid from Tiarella polyphylla, Regulation of Type 1 Procollagen and MMP-1 in Ultraviolet Irradiation of Cultured Old Age Human Dermal Fibroblasts  

Moon, Hyung-In (Department of Dematology,Seoul National University, College of Medicine, and Clinical Research Institute, Seoul National University Hospital)
Lee, Joong-Ku (Korea Research Institute of Bioscience and Biotechnology)
Zee, Ok-Pyo (College of Pharmacy, SungKyunKwan University)
Chung , Jin-Ho (Department of Dematology,Seoul National University, College of Medicine, and Clinical Research Institute, Seoul National University Hospital)
Publication Information
Archives of Pharmacal Research / v.27, no.10, 2004 , pp. 1060-1064 More about this Journal
Abstract
Although many studies have been performed to elucidate the molecular consequences of ultraviolet irradiation, little is known about the effect of natural products. Ultraviolet irradiation is widely considered to be an environmental stress. Here we investigated the effect of 3,23-dihydroxy- 20(29)-lupen-27-oic acid on the regulation of MMP-1 and type 1 procollagen in Ultraviolet irradiation of cultured old age human dermal fibroblasts. 3, 23-dihydroxy-20(29)-lupen-27- oic acid was isolated from Tiarella polyphylla D. Don (Saxifragaceae). Among them, 3, 23- dihydroxy-20(29)-lupen-27-oic acid induced the regulation of Type 1- procollagen and reduced the regulation of MMP-1 at the protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that 3, 23-dihydroxy-20(29)-lupen-27-oic acid plays an important role in the induction of Type 1-procollagen and reduction of MMP-1 by ultraviolet irradiation in old age human dermal fibroblasts.
Keywords
Tiarella polyphylla; 3, 23-Dihydroxy-20(29)-lupen-27-oic acid; MMP-1; Type 1-procollagen; Ultraviolet irradiation; Old age human dermal fibroblasts;
Citations & Related Records

Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
연도 인용수 순위
1 Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z. Q., Varani, J., Kang, S., and Voorhees, J. J., Molecular basis of suninduced premature skin ageing and retinoid antagonism. Nature, 379, 335-339 (1996)   DOI   ScienceOn
2 Park, S. H., Oh, S. R., Jung, K. Y., Lee, I. S., Ahn, K. S., Kim, J. G., Lee, J. J., and Lee, H. K., Anticomplement activities of oleanolic acid monodesmosides and bisdesmosides isolated from Tiarella polyphylla. Arch. Pharm. Res., 22, 428-431 (1999)   DOI   ScienceOn
3 Park, S. H., Oh, S. R., Ahn, K. S., Kim, J. G., and Lee, H. K., Structure determination of a new lupane-type triterpene, tiarellic acid, isolated from Tiarella polyphylla. Arch. Pharm. Res., 25, 57-60 (2002)   DOI   ScienceOn
4 Bernhard, E. J., Gruber, S. B., and Muschel, R. J., Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc. Nat. Acad. Sci. U.S.A., 91,4293-4297 (1994)   DOI   ScienceOn
5 Chambers, A. F. and Matrisian, L.M, Changing views of the role of matrix metalloproteinases in metastasis. J. Natl. Cancer Inst., 89, 1260-1270(1997)   DOI   ScienceOn
6 Gilchrest, B. A., Skin aging and photoaging: an overview. J. Am. Acad. Dermatol., 21,610-613 (1989)   DOI   PUBMED   ScienceOn
7 Seo, J. Y., Lee, S. H., Youn, C. S., Choi, H. R., Rhie, G. E., Cho, K. H., Kim, K. H., Park, K. C., Eun, H. C., and Chung, J. H., Ultraviolet radiation increases tropoelastin mRNA expression in the epidermis of human skin in vivo. J. Invest. Dermatol., 116, 915-919 (2001)   DOI   ScienceOn
8 Lee, Y. N. (1996) Flora of Korea, p. 287, Kyo-Hak Publishing Co., Seoul
9 Mosmann, T., Rapid colorimetric assay for cellular growth and survival:application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63 (1983)   DOI   PUBMED   ScienceOn
10 Varani, J., Warner, R. L., Gharaee-Kermani, M., Phan, S. H., Kang, S., Chung. J. H., Wang, Z. Q., Datta, S. C., Fisher, G. J., and Voorhees, J. J., Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J. Invest. Dermatol., 114,480-486 (2000)   DOI   ScienceOn