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Anti-Tumor Activities of Decursinol Angelate and Decursin from Angelica gigas  

Lee, Sang-Hyun (Natural Products Research Institute and College of Pharmacy, Seoul National University, College of Pharmacy, Seoul National University)
Lee, Yeon-Sil (Natural Products Research Institute and College of Pharmacy, Seoul National University)
Jang, Sang-Hoon (Natural Products Research Institute and College of Pharmacy, Seoul National University)
Shin, Kuk-Hyun (Natural Products Research Institute and College of Pharmacy, Seoul National University)
Kim, Bak-Kwang (College of Pharmacy, Seoul National University)
Kang, Sam-Sik (Natural Products Research Institute and College of Pharmacy, Seoul National University, College of Pharmacy, Seoul National University)
Publication Information
Archives of Pharmacal Research / v.26, no.9, 2003 , pp. 727-730 More about this Journal
Abstract
The in vivo anti-tumor activities of decursinol angelate (1) and decursin (2) isolated from the roots of Angelica gigas were investigated. These two compounds, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume of mice inoculated with Sarcoma-180 tumor cells. These results suggest that decursinol angelate (1) and decursin (2) from A. gigas have anti-tumor activities.
Keywords
Angelica gigas; Umbelliferae; Anti-tumor activity; Oecursinol angelate; Decursin;
Citations & Related Records

Times Cited By Web Of Science : 59  (Related Records In Web of Science)
Times Cited By SCOPUS : 56
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