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Synthesis and $PGE_2$ Inhibitory Activity of Vinylated and Allylated Chrysin Analogues  

Dao, Tran-Thanh (College of Pharmacy, Kangwon National University)
Oh, Jeong-Won (College of Pharmacy, Kangwon National University)
Chi, Yeon-Sook (College of Pharmacy, Kangwon National University)
Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
Sin, Kwan-Seog (College of Pharmacy, Kangwon National University)
Park, Hae-Il (College of Pharmacy, Kangwon National University)
Publication Information
Archives of Pharmacal Research / v.26, no.8, 2003 , pp. 581-584 More about this Journal
Abstract
Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2 -hydroxy-3 -iodo-4 ,6 -dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from chrysin in 3 steps. Synthesized chrysin analogues (4, 5 and 8) showed moderate inhibitory activities of $PGE_2$ production from LPS-induced RAW 264.7 cells.
Keywords
Prenylated flavonoids; Allylated chrysin analogues; Vinylated chrysin analogues; Anti-inflammatory activity; Cyclooxygenase-2; $PGE_2$ production; Stille reaction;
Citations & Related Records

Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
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