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Antioxidant Constituents from the Stem of Sorghum bicolor  

Kwon, Yong-Soo (College of Pharmacy, Kangwon National University)
Kim, Chang-Min (College of Pharmacy, Kangwon National University)
Publication Information
Archives of Pharmacal Research / v.26, no.7, 2003 , pp. 535-539 More about this Journal
Abstract
The EtOAc soluble fraction from the stem of Sorghum bicolor showed a strong free radical scavenging activity. Five major compounds were isolated from this fraction. They were identified by spectral data as methyl ferulate (1), methyl p-hydroxycinnamate (2), p-hydroxybenzaldehyde (3), tricin (4), and quercetin 3,4 -dimethyl ether (5). Among these compounds, 1 exhibited a strong, free radical scavenging activity on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) with an $IC_50$ value of 0.7 $\mu$M. We further studied the effects of these isolated compounds on the lipid peroxidation in rat liver microsomes induced by non-enzymatic method. All five compounds showed anti-lipid peroxidation activity ($IC_50$ values of 0.5, 0.4, 0.3 and 0.3 $\mu$ M, respectively).
Keywords
Sorghum bicolor; Phenolics; Antioxidant; Free radical scavenging activity; DPPH(1,1-diphenyl-2-picrylhydrazyl) radical; Lipid peroxidation;
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