Browse > Article

${\gamma}-Pyrone$ Derivatives, Kojic Acid Methyl Ethers from a Marine-Derived Fungus Altenaria sp.  

Li, Xifeng (Department of Chemistry, Pukyong National University)
Jeong, Jee-Hean (R＆D Center, Coreana Cosmetics Co. Ltd.)
Lee, Kang-Tae (R＆D Center, Coreana Cosmetics Co. Ltd.)
Rho, Jung-Rae (Marine Natural Products Laboratory, Korea Ocean Research ＆ Development Institute)
Choi, Hong-Dae (Department of Chemistry, Dongeui University)
Kang, Jung-Sook (College of Dentistry, Pusan National University)
Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
Publication Information
Archives of Pharmacal Research / v.26, no.7, 2003 , pp. 532-534 More about this Journal
Abstract
Kojic acid dimethyl ether (1), and the known kojic acid mono methyl ether (2), kojic acid (3) and phomaligol A (4) have been isolated from the organic extract of the broth of the marine-derived fungus Altenaria sp. collected from the surface of the marine green alga Ulva pertusa. The structures were assigned on the basis of comprehensive spectroscopic analyses. Each isolate was tested for its tyrosinase inhibitory activity. Kojic acid (3) was found to have significant tyrosinase inhibitory activity, but compounds 1, 2, and 4 were found to be inactive.
Keywords
Marine fungus; Altenaria sp.; Kojic acid; Kojic acid methyl ether; Phomaligol; Tyrosinase inhibitory activity;
Citations & Related Records

Times Cited By Web Of Science : 6  (Related Records In Web of Science)
Times Cited By SCOPUS : 7
연도 인용수 순위
1 Buckingham, J., Macdonald, F. M., and Bradley, H. M. (Eds.), Dictionary of Natural Products, Vol. 10, Chapman & Hall, London, p. 3037, (1994)
2 Kamal, A., Haider, Y., Akhtar, R., and Qureshi, A. A., Biochemistry of microorganisms. XVIII. Isolation of kamusol and structure of kojic acid, mannitol, kojic acid methyl ether, methyl 2,4,6-octatriene-1-carboxylate, and tetronic acid, metabolic products of Aspergillus sulphureus. Pakistan J. Sci. Industrial Res., 65, 63-67 (1971)
3 Li, C. Y. and Wu, T. S., Constituents of the stigmas of Crocus sativus and their tyrosinase inhibitory activity, J. Nat. Prod., 65, 1452-1456 (2002)   DOI   ScienceOn
4 Li, X., Li, Y., Jeong, J. H., Lee, K. T., Choi, H. D., and Son, B. W., Screening of tyrosinase inhibiting activity from the marinederived fungus. Kor. J. Pharmacogn., 34, 138-141 (2003)
5 Fenical, W., Marine biodiversity and the medicine cabinet. the status of new drugs from marine organisms. Oceanography, 9, 23-27 (1996) and references cited therein   DOI   ScienceOn
6 Poonia, N. S. and Yadav, B. P., Coordinative role of alkali cations in organic synthesis. Selective metylations of 5-hydroxy-2-hydroxymethyl-$\gamma$-pyrone. J. Org. Chem., 43, 2842-2844 (1978)   DOI
7 Li, Y., Li, X. F., Kim, D. S., Choi, H. D., and Son, B. S., Indolyl alkaloid derivatives, Nb-acetyltryptamine and oxaline from a marine-derived fungus. Arch. Pharm. Res., 26, 21-23 (2003)   DOI   PUBMED
8 Pietra, F., Secondary metabolites from marine microorganisms: bacterial, protozoa, algae and fungi. Achievements and prospects. Nat. Prod. Rep., 14, 453-464 (1997)   DOI   PUBMED   ScienceOn
9 Pedras, M. S. C., Morales, V. M., and Taylor, J. L., Phomaligols and phomaligadiones: new metabolites from the blackleg fungus. Tetrahedron, 49, 8317-8322 (1993)   DOI   ScienceOn
10 Faulkner, D. J., Marine natural products. Nat. Prod. Rep., 19, 1-48 (2002)   PUBMED
11 Schmitz, F. J., Cited in International Symposium on Natural Products Research, Proceedings of the Third Symposium on Pharmaceutical Science. Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, pp. 73-82 (2000)