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DNA Topoisomerases I and II Inhibitory Activity of Constituents Isolated from Juglans mandshurica  

Li, Gao (College of Pharmacy, Yeungnam University)
Lee, Sun-Young (Department of Biochemistry, College of Natural Sciences, Yeungnam University)
Lee, Kyeung-Seon (College of Pharmacy, Yeungnam University)
Lee, Sung-Won (College of Pharmacy, Yeungnam University)
Kim, Sang-Hyun (College of Pharmacy, Yeungnam University)
Lee, Seung-Ho (College of Pharmacy, Yeungnam University)
Lee, Chong-Soon (Department of Biochemistry, College of Natural Sciences, Yeungnam University)
Woo, Mi-Hee (College of Pharmacy, Catholic University)
Son, Jong-Keun (College of Pharmacy, Yeungnam University)
Publication Information
Archives of Pharmacal Research / v.26, no.6, 2003 , pp. 466-470 More about this Journal
Abstract
Nine diarylheptanoids (1-9), one triterpene (10), one sesquiterpenoid (11), one naphthoquinone (12), four tetralones (13-16), one naphthalene carboxylic acid glucoside (17) and six naphthalenyl glycosides (18-23) were isolated from the roots of Juglans mandshurica Maximowicz (Juglandaceae), and their structures determined from the chemical and spectral data. Here, we report the inhibitory effects, on the DNA topoisomerases I and II activities, of all these compounds. Compounds 10 and 23 showed more potent inhibitory effects, on the DNA topoisomerases I and II (94.0 and 86.0% inhibitions at the concentration of 5 $\mu$ g/mL, respectively), than the positive control compounds, camptothecin and etoposide.
Keywords
Juglans mandshurica; DNA topoisomerases I and II inhibitors;
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Times Cited By Web Of Science : 7  (Related Records In Web of Science)
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