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Antibacterial Coumarins from Angelica gigas Roots  

Lee, Sanghyun (Natural Products Research Institute, Seoul National University)
Shin, Dong-Sun (Natural Products Research Institute, Seoul National University)
Kim, Ju-Sun (Natural Products Research Institute, Seoul National University)
Oh, Ki-Bong (Natural Products Research Institute, Seoul National University, Graduate School of Agricultural Biotechnology, Seoul National University)
Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
Publication Information
Archives of Pharmacal Research / v.26, no.6, 2003 , pp. 449-452 More about this Journal
Abstract
Systematic fractionation of Angelica gigas roots led to the isolation of linear furano(pyrano)coumarins such as bergapten (1), decursinol angelate (2), decursin (3), nodakenetin (4) and nodakenin (5). The antibacterial activities of those compounds against pathogenic bacteria were investigated. Among the compounds tested, decursinol angelate (2) and decursin (3) exhibited significant antibacterial activity against Bacillus subtilis with the minimum inhibitory concentrations (MICs) of 50 and $12.5{\;}{\mu}g/mL$, respectively.
Keywords
Angelica gigas; Umbelliferae; Antibacterial activity; Coumarin; MIC;
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Times Cited By Web Of Science : 44  (Related Records In Web of Science)
Times Cited By SCOPUS : 38
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