1 |
Autenrieth, I. B., Bucheler, N., Bohn, E., Heinze, G., and Horak, I., Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation. Gut, 41, 793-800 (1997)
DOI
ScienceOn
|
2 |
Brandwein, S. L., McCabe, R. P., Cong, Y., Waites, K. B., Ridwan, B. U., Dean, P. A., Ohkusa, T., Birkenmeier, E. H., Sundberg, J. P., and Elson, C. O., Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J. Immunol., 159, 44-52 (1997)
PUBMED
|
3 |
Burich, A., Hershberg, R., Waggie, K., Zeng, W., Brabb, T., Westrich, G., Viney, J. L., and Maggio-Price, L., Helicobacterinduced inflammatory bowel disease in IL-10 and T cell deficient mice. Am. J. Physiol., 281, G764-778 (2001)
|
4 |
Hiatt, R. A. and Kaufman, L., Epidemiology of inflammatory bowel disease in a defined northern California population. West. J. Med., 149, 541-546 (1988)
|
5 |
Hornquist, C. E., Lu, X., Rogers-Fani, P. M., Rudolph, U., Shappell, S., Birnbaumer, L., and Harriman, G. R., Gai2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J. Immunol., 158, 1068-1077 (1997)
PUBMED
|
6 |
Maggio-Price, L., Shows, D., Waggie, K., Burich, A., Zeng, W., Escobar, S., Morrissey, P., and Viney, J. L., Helicobacter bilis infection accelerates and H. hepaticus infections delays the development of colitis in multiple drug resistance deficient (mdr1a-/-) mice. Am. J. Path., 160, 739-751 (2002)
DOI
ScienceOn
|
7 |
Mombaerts, P., Mizoguchi, E., Grusby, M. J., Glimcher, L. H., Bhan, A. K., and Tonegawa, S., Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell, 75, 275-282 (1993)
DOI
ScienceOn
|
8 |
Schorle, H., Holtschkle, T., Hunig, T., Schimpl, A., and Horak, I., Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature, 352, 621-624 (1991)
DOI
ScienceOn
|
9 |
Snider, D. P., Liang, H., Switzer, I., and Underdown, B. J., IgA production in MHC class II-deficient mice is primarily a function of -1a cells. Inter. Imm., 11, 191-198 (1999)
DOI
ScienceOn
|
10 |
Thiebaut, F., Tsuruo, T., Hamada, H., Bgottesman, M. M., Pastan, I., and Willingham, M. C., Cellular localizaton of the multidrug resistance gene product in normal human tissues. Proc. Natl. Acad. Sci. USA, 84, 7735-7738 (1987)
DOI
ScienceOn
|
11 |
Mahler, M., Bristol, I. J., Leiter, E. H., Workman, A. E., Birkenmeier, E. H., Elson, C. O., and Sundberg, J. P., Differential susceptibility of inbred mouse strains to dextran sulfate sodiuminduced colitis. Am. J. Physiol., 274, G544-G551 (1998)
PUBMED
|
12 |
Ohman, L., Franzen, L., Rudolph, U., Harriman, G. R., and Hornquist, E. H., Immune activation in the intestinal mucosa before the onset of colitis in Gai2-deficient mice. Scand. J. Immunol., 52, 80-90 (2000)
DOI
ScienceOn
|
13 |
Jaffee, B. D., Manos, E. J., Collins, R. J., Czerniak, P. M., Favata, M. F., Magolda, R. L., Scherle, P. A., and Trzaskos, J. M., Inhibition of MAP kinase kinase (MEK) results in an antiinflammatory response in vivo. Biochem. Biophys. R. Comm., 268, 647-651 (2000)
DOI
ScienceOn
|
14 |
Rudolph, U., Finegold, M. J., Rich, S. S., Harriman, G. R., Srinivasan, Y., Brabet, P., Boulay, G., Bradley, A., and Birnbaumer, L., Ulcerative colitis and adenocarcinoma of the colon in Gai2-deficinet mice. Nat. Gen., 10, 143-150 (1995a)
DOI
ScienceOn
|
15 |
Stowe, S. P., Redmond, S. R., Stormont, J. M., Shah, A. N., Chessin, L. N., Segal, H. L., and Chey, W. Y., An epidemiologic study of inflammatory bowel disease in Rochester, New York. Gastroenterology, 98, 104-110 (1990)
DOI
PUBMED
|
16 |
Sundberg, J. P., Elson, C. O., Bedgian, H., and Birkenmeier, H., Spontaneous heritable colitis in a new substrain of C3H/HeJ mice. Gastroenterology, 107, 1726-1735 (1994)
DOI
PUBMED
|
17 |
Rudolph, U., Finegold, M. J., Rich, S. S., Harriman, G. R., Srinivasan, Y., Brabet, P., Bradley, A., and Birnbaumer, L., Gi2a protein deficiency: A model for inflammatory bowel disease. J. Clin. Immunol., 15, 101S-105S (1995b)
DOI
PUBMED
|
18 |
Waidmann, M., Allemand, Y., Lehmann, J., Genaro, S. D., Bucheler, N., Hamann, A, and Autenrieth, I. B., Microflora reactive IL-10 producing regulatory T cells are present in the colon of IL-2 deficient mice but lack efficacious inhibition of IFN- and TNF- production. Gut, 50, 170-179 (2002)
DOI
ScienceOn
|
19 |
Gillen, C. D., Walmsley, R. S., Prior, P., Andrews, H. A., and Allan, R. N., Ulcerative colitis and Crohn's disease: A comparison of the colorectal cancer risk in extensive colitis. Gut, 35, 1590-1592 (1994)
DOI
ScienceOn
|
20 |
Hermiston, M. L. and Gordon, J. I., Inflammatory bowel disease and adenomas in mice expressing a dominant negative Ncadherin. Science, 270, 1203-1207 (1995)
DOI
PUBMED
ScienceOn
|
21 |
Simpson, S. J., Mizoguchi, E., Allen, D., Bhan, A. K., and Terhost, C., Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur. J. Immunol., 25, 2618-2625 (1995)
DOI
ScienceOn
|
22 |
Desvignes, C., Bour, H., Nicolas, J. F., and Kaiserlain, D., Lack of oral tolerance but oral priming for contact sensitivity to dinitrofluorobenzene in major histocompatibility complex class II-deficient mice and in CD4(+) T cell-depleted mice. Eur. J. Imm., 26, 1756-1761, (1996)
DOI
ScienceOn
|
23 |
Ehrhardt, R. O., Ludviksson, B. R., Gray, B., Neurath, M., and Strober, W., Induction and prevention of colonic inflammation in IL-2-deficient mice. J. Immunol., 158, 566-573 (1997)
PUBMED
|
24 |
Ma, A., Datta, M., Margosian, E., Chen, J., and Horak, I., T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. J. Exp. Med., 182, 1567-1572 (1995)
DOI
ScienceOn
|
25 |
Schinkel, A. H., Smit, J. J. M., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., van der Valk, M. A., Robanus-Maandag, E. C., te Riele, H. P. J., Berns, A. J. M., and Borst, P., Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell, 77, 491-502 (1994)
DOI
ScienceOn
|
26 |
Schultz, M., Tonkonogy, S. L., Sellon, R. K., Veltkamp, C., Godfrey, V. L., Kwon, J., Grenther, W. B., Balish, E., Horak, I., and Sartor, R. B., IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation. Am. J. Physiol., 276, G1461-G1472 (1999)
PUBMED
|
27 |
Mizoguchi, A., Mizoguchi, E., Chiba, C., Spiekermann, G. M., Tonegawa, S., Nagler-Anderson, C., and Bhan, A. K., Cytokine imbalance and autoantibody production in T cell receptor- mutant mice with inflammatory bowel disease. J. Exp. Med., 183, 847-856 (1996)
DOI
ScienceOn
|
28 |
McDonald, S. A. C., Palmen, M. J. H. J., Van Rees, E. P., and MacDonald, T. T., Characterization of the mucosal cell mediated immune response in IL-2 knockout mice before and after the onset of colitis. Immunology, 91, 73-80 (1997)
DOI
ScienceOn
|
29 |
Shah, S. A., Simpson, S. J., Brown, L. F., Comiskey, M., de Jong, Y. P., Allen, D., and Terhorst, C., Development of colonic adenocarcinomas in a mouse model of ulcerative colitis-associated colon cancer. Gastroenterology, 120, A447 (2001)
DOI
|
30 |
Panwala, C. M., Jones, J. C., and Viney, J. L., A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J. Immunol., 161, 5733-5744 (1998)
PUBMED
|
31 |
Uhlig, H. H., Hornquist, E. H., Bache, L. O., Rudolph, U., Birnbaumer, L., and Mothes, T., Antibody response to dietary and autoantigens in Gai2-deficient mice. Eur. J. Gastro. Hepato., 13, 1421-1429 (2001)
DOI
ScienceOn
|
32 |
Gupta, S. K., Gallego, C., Johnson, G. L., and Heasley, L. E., MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts. J. Biol. Chem., 267, 7987-7990 (1992)
PUBMED
|
33 |
Cong, Y., Brandwein, S. L., McCabe, R. P., Lazenby, A., Birkenmeier, E. H., Sundberg, J. P., and Elson, C. O., CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: Increased T helper cell type 1 response and ability to transfer disease. J. Exp. Med., 187, 855-864 (1998)
DOI
ScienceOn
|
34 |
Grusby, M. J., Johnson, R. S., Papaioannou, V. E., and Glimcher, L. H., Depletion of CD4+ T cells in major histocompatability complex class II deficient mice. Science, 253, 1417-1420 (1991)
DOI
PUBMED
|
35 |
Takashi, I., Kiyono, H., and Hamada, S., CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor a chain deficient mice. Gastroenterology, 112, 1876-1886 (1997)
DOI
PUBMED
ScienceOn
|
36 |
Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C., and Horak, I., Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell, 75, 253-261 (1993)
DOI
ScienceOn
|
37 |
Mombaerts, P., Clarke, A. R., Hooper, M. L., and Tonewaga, S., Creation of a large genomic deletion at the T-cell antigen receptor -subunit locus in mouse embryonic stem cells by gene targeting. Proc. Natl. Acad. Sci. USA, 88, 3084-3087 (1991)
DOI
ScienceOn
|
38 |
Elson, C. O., Cong, Y., and Sundberg J., The C3H/HeBir mouse model: a high susceptibility phenotype for colitis. Int. Rev. Immunol., 19, 63-75 (2000)
DOI
ScienceOn
|
39 |
Mombaerts, P., Clarke, A. R., Rudnicki, M. A., Iacomini, J., Itohara, S., LaFaille, J. J., Wang, L., Ichikawa, Y., Jaenisch, R., Hooper, M. L., and Tonegawa, S., Mutations in T-cell antigen receptor genes a and b block thymocyte development at different stages. Nature, 360, 225-231 (1992)
DOI
ScienceOn
|
40 |
Sohn, K., Shah, S. A., Reid, S., Choi, M., Carrier, J., Comiskey, M., Terhorst, C., and Kim, Y., Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and -microglobulin-deficient mouse. Cancer Res., 61, 6912-6917 (2001)
PUBMED
|
41 |
Croop, J. M., Raymond, M., Haber, D., Devault, A., Arceci, R. J., Gros, P., and Housman, D. E., The three mouse multidrug resistance (mdr) genes are expressed in a tissue specific manner in normal mouse tissue. Mol. Cell. Biol., 9, 1346-1350 (1989)
DOI
PUBMED
|