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Tyrosine Kinase is Involved in Hemin-Induced Pyresis  

Lee, Sang-Ho (Lab. of Pharmacology, College of Pharmacy, Sungkyunkwan University)
Jang, Choon-Gon (Lab. of Pharmacology, College of Pharmacy, Sungkyunkwan University)
Lee, Seok-Yong (Lab. of Pharmacology, College of Pharmacy, Sungkyunkwan University)
Publication Information
Archives of Pharmacal Research / v.26, no.5, 2003 , pp. 411-415 More about this Journal
Abstract
To investigate the mechanisms involved in hemin-induced febrile response, the rectal temperature of rats were measured after intracerebroventricular (i.c.v.) injections of hemin, with or without antagonists. Hemin ($10\mu\textrm{g}$) elicited a significant febrile response, which lasted from 30 min, to more than 6 h, after its administration, but this was not the case with biliverdin (i.c.v.) and bilirubin (i.c.v.). The hemin-induced febrile response was significantly inhibited by pretreatment with an inhibitor of tyrosine kinase (genistein), but not by pretreatment with an inhibitor of protein kinase C (chelerythrine) and a scavenger of iron (deferoxamine). These results suggest that tyrosine kinase is involved in the hemin-induced febrile response.
Keywords
Hemin; Carbon monoxide; Tyrosine kinase;
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1 Atkins, E. and Bodel, P., Clinical fever: its history, manifestations and pathogenesis. Fed. Proc., 38, 57-63 (1979)   PUBMED
2 Blatteis, C. M. and Sehic, E., Prostaglandin $E_2$; a putative fever mediator. In: Mackowiak P. A., editor. Fever: basic mechanisms and management. 2nd ed. New York: Raven-Lippincott, pp. 117-148 (1997)
3 Hiromi, T. and Mayumi, M., In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats. Brain Res., 852, 367-373 (2000)   DOI   ScienceOn
4 Kluger, M. J., Fever: role of pyrogens and cryogens, Physiol. Rev., 71, 93-127 (1991)   DOI   PUBMED
5 Lin, M. T. and Lin, J. H., Involvement of tyrosine kinase in the pyrogenic fever exerted by NOS pathways in organum vasculosum laminae terminals. Neuropharmacology, 39, 347-352 (2000)   DOI   ScienceOn
6 Milton, A. S., Thermoregulatory actions of eicosanoids in the central nervous system with particular regard to the pathogenesis of fever. Ann. NY Acad. Sci., 559, 392-410 (1989)   DOI   PUBMED   ScienceOn
7 Solomon, H. S., Samie R. J., and Randa, Z., Nitric oxide and carbon monoxide: parallel roles as neural messengers. Brain Res. Rev., 26, 167-175 (1998)   DOI   ScienceOn
8 Solomon, H., Snyder, M. D., and David, E. Baranano., Heme oxygenase: a font of multiple messengers. Neuropsychopharmacology, 25(3), 294-298 (2001)   DOI   ScienceOn
9 Steiner, A. A. and Branco, L. G., Central CO-heme oxygenase pathway raises body temperature by a prostaglandin-independent way. J. Appl. Physiol., 88, 1607-1613 (2000)   DOI   PUBMED
10 Stocker, R., Glazer, A. N., and Ames, B. N., Antioxidant activity of albumin-bound bilirubin. Proc. Natl. Acad. Sci. USA., 84, 5918-5922 (1987)   DOI   ScienceOn
11 Jang, C. G., Lee, S. J., Yang, S. I., Kim, J. H., Sohn, U. D., and Lee, S. Y., Carbon monoxide as a novel central pyrogenic mediator. Arch. Pharm. Res., 25, 343-348 (2002)   DOI   ScienceOn
12 Kluger, M. J., Kozak, W., Leon, L., Soszynski, D., and Conn, C. A., Cytokines and fever. Neuroimmunomodulation, 2, 216-223 (1995)   DOI   ScienceOn
13 Maines, M. D., Carbon monoxide : an emerging regulator of cGMP in the brain. Mol. Cell. Neurosci., 4, 389-397 (1993)   DOI   ScienceOn
14 Abraham, N. G., Lin, J. H. C., Schwartzman, M. L., Levere, R. D., and Shibahara, S., The physiological significance of heme oxygenase. Int. J. Biochem., 20, 543-558 (1988)   DOI   ScienceOn
15 Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates. 3rd ed., Academic Press. Sydney (1997)
16 Kluger, M. J., Fever: role of pyrogens and cryogens. Physiol. Rev., 71, 93-127 (1991)   DOI   PUBMED
17 Tsushima, H. and Mori, M., In vivo evidence that activation of tyrosine kinase is a trigger for lipopolysaccharide-induced fever in rats. Brain Res., 852, 367-373 (2000)   DOI   ScienceOn
18 Steiner, A. A., Colombari, E., and Branco, L. G., Carbon monoxide as a novel mediator of the febrile response in the central nervous system. Am. J. Physiol., 277, R499-R507 (1999)   PUBMED
19 Tsushima, H. and Mori, M., Involvement of protein kinase C and tyrosine kinase in lipopolysaccharide-induced anorexia. Pharmacol. Biochem. Behav., 69, 17-22 (2001)   DOI   ScienceOn
20 Jung, J. K. and Lee, S. Y., Pyrogenic effects of nitric oxide and carbon monoxide. Proceeding of the 51st Annual Meeting of Korean Society of Pharmacology, 62, 55-61 (1999)
21 Pela I. R., Ferreira, M. E. S., Melo, M. C. C., Silva, C. A. A., Coelho, M. M., and Valenzuela, C. F., Evidence that plateletderived growth factor may be a novel endogenous pyrogen in the central nervous system. Am. J. Physiol., 278, R1275-R1281, 2000   DOI
22 Dawson, T. M. and Snyder, S. H., Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J. Neurosci., 14, 5147-5159 (1994)   PUBMED
23 Maines, M. D., The heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J., 2, 2557-2568 (1988)   DOI   PUBMED
24 Ullrich, A. and Schlessinger, J., 1990. Signal transduction by receptors with tyrosine kinase activity. Cell, 61, 203-212 (1990)   DOI   ScienceOn
25 Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., and Ames, B. N., Bilirubin is an antioxidant of possible physiological importance. Science, 235, 1043-1046 (1987)   DOI   PUBMED
26 Maines, M. D., The heme oxygenase system : a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol., 37, 517-554 (1997)   DOI   PUBMED   ScienceOn
27 Marks, G. S., Brien, J. F., Nakatsu, K., and McLaughlin, B. E., Does carbon monoxide have a physiological function?. Trens Pharmacol. Sci., 12, 185-188 (1991)   DOI   ScienceOn
28 Ihle, J. N., Cytokine receptor signaling. Nature, 377, 591-594 (1995)   DOI   PUBMED   ScienceOn
29 Steiner, A. A. and Branco, L. G., Carbon monoxide is the heme oxygenase product with a pyretic action: evidence for a cGMP signaling pathway. Am. J. Physiol., 280, R448-R457 (2001)
30 Belanger, S., Lavoie, J. C., and Chessex, P., Influence of bilirubin on the antioxidant capacity of plasma in newborn infants. Biol. Neonat., 71, 233-238 (1997)   DOI
31 Rothwell, N. J., CNS regulation of thermogenesis. Crit. Rev. Neurobiol., 8, 1-10 (1994)   PUBMED
32 Johnson, R. A., Kozma, F., and Colombari, E., Carbon monoxide: from toxin to endogenous modulator of cardiovascular functions. Braz. J. Med. Biol. Res., 32, 1-14 (1999)   DOI   PUBMED
33 Charles, A. D., Silvia, G., and Tamas, B., Fever: links with an ancient receptor. Current Biol., 9, R147-R150 (1999)   DOI   ScienceOn
34 Kozak, W., Klir, J. J., Conn, C. A., and Kluger, M. J., Attenuation of lipopolysaccharide fever in rats by protein kinase C inhibitors. Am. J. Physiol., 273, R873-R879 (1997)   PUBMED