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Anti-Aspergillus Activities of Plant Essential Oils and Their Combination Effects with Ketoconazole or Amphotericin B  

Shin, Seung-Won (College of Pharmacy, Duksung Women s University)
Publication Information
Archives of Pharmacal Research / v.26, no.5, 2003 , pp. 389-393 More about this Journal
Abstract
The essential oils from Cedrus atlantica, Styrax tonkinensis, Juniperus communis, Lavandula angustifolia, Melaleuca alternifolia, Pelargonium graveolens, Pogestemon patchouli and Rosmarinus officinalis were analyzed by GC-MS. Antifungal activities of the oils were investigated by disk diffusion assay and the broth dilution method against Aspergillus niger and A. flavus. The effects of geraniol and the essential oil fraction from P. graveolens on the antifungal activity of amphotericin Band ketoconazole were examined using a checkerboard microtiter assay against both Aspergillus fungi. Most of the tested essential oils, with the exception of C. atlantica, J. communis, and P. patchouli, significantly inhibited growth of A. niger and to a lesser extent that of A. fIavus, with MICs (minimal inhibitory concentrations) in the range 0.78-12.5 mg/mL. The essential oil fraction of P. graveolens and its main components, geraniol and citronellol, exhibited additive effects with amphotericin B and with ketoconazole against both Aspergillus species, resulting in fractional inhibitory concentration (FIC) indices ranging from 0.52 to 1.00.
Keywords
Aspergillus niger; A. flavus; Essential oils; Amphotericin B; Ketoconazole; Geraniol; Citronellol; Synergism;
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1 Godwin, D. A. and Michniak, B. B., Influence of drug lipophilicity on terpenes as transdermal penetration enhancers. Drug. Dev. Ind. Pharm., 25, 905-915 (1999)   DOI   ScienceOn
2 Otsubo, T., Maesaki, S., Hossain, M. A., Yamamoto, Y., Tomono, K., Tashiro, T., Seki, J., Tomii, Y., Sonoke, S., and Kohno, S., In vitro and in vivo activities of NS-718, a new lipid nanosphere incorporating Amphotericin B against Aspergillus fumigatus. Antimicrob. Agents Chemother., 43, 471-475 (1999)   PUBMED
3 Zhirong, Y., Wanqing, L., and Weihua, P., Invasive pulmonary aspergillosis in non-neutropenic patients treated with liposomal amphotericin B. Mycoses, 42, 679-682 (1999)   DOI   ScienceOn
4 Davidson, P. M. and Parish, M. E., Methods for testing the efficacy of food antimicrobials. Food Technology, 43, 148-155 (1989)
5 Shin, S. and Kang, C. A., Antifungal activity of the essential oil of Agastache rugosa Kuntze and its synergism with ketoconazole. Lett. Appl. Microbiol., 36, 111-115 (2003)   DOI   ScienceOn
6 Dikshit, A., Naqvi, A. A., and Husain, A., Schinus molle: a new source of natural fungitoxicant. Appl. Environ. Microbiol., 51, 1085-1088 (1986)   PUBMED
7 Gundidza, M., Antimicrobial of essential oil from Schinus molle. Cent. Afr. J. Med., 39, 231-4 (1993)   PUBMED
8 Voda, K., Boh, B., Vrtanik, M., and Pohleven, F., Effect of the antifungal activity of oxygenated aromatic essential oil compounds on the white-rot Tremetes versicolor and the brown-rot Coniophora puteana, Int. Biodeter. Biodegr. In press, Uncorrected proof (2002)
9 Adam. K., Sivropoulou, A., Kokkini, S., Lanaras, T., and Arsenakis, M., Antifungal activities of Origanum vulgare subsp. hirtum, Mentha spicata, Lavandula angustifolia, and Salvia fruticosa essential oils against human pathogenic fungi. J. Agr. Food. Chem., 46, 1739-1745 (1998)   DOI   ScienceOn
10 Lis-Balchin, M., Deans, S. G., and Hart, S., Bioactive geranium oils from different commercial sources. J. Essent. Oil Res., 8, 281-290 (1996)   DOI   ScienceOn
11 Hammer, K., Carson, C. F., and Riley, T. V., In-vitro activity of essential oils, in particular Melaleuca alternifolia (tea tree) oil and tea tree oil products, against Candida spp. J. Antimicrob. Chemother., 42, 591-595 (1998)   DOI   PUBMED
12 Garg., S. C. and Siddiqui, N., Antifungal activity of some essential oil isolates. Pharmazie, 47, 467-468 (1992)   PUBMED
13 Giordani, R., Trebaux, J., Masi, M., and Regli, P., Enhanced antifungal activity of ketoconazole by Euphorbia characias latex against Candida albicans. J. Ethnopharmacol., 78, 1-5 (2001)   DOI   ScienceOn
14 Yoon, S. Y., Eo, S. K., Lee, D. K., and Han S. S., Antimicrobial activity of Ganoderma lucidum extract alone and in combination with some antibiotics. Arch. Pharm. Res., 6, 438-442 (1994)
15 Jayashree, T. and Subramanyam, C., Antiaflatoxigenic activity of eugenol is due to inhibition of lipid peroxidation. Lett. Appl. Microbiol., 28, 189-193 (1999)   DOI   ScienceOn
16 Bidlack, W. R., Omaye, S. T., Meskin, M. S., and Topham, D., Phytochemicals as bioactive agents. Technomic Publishing Company, Lancaster, pp. 106-110 (2000)
17 Mahmoud, A. L., Antifungal and anti-aflatoxigenic properties of some essential oil constituents. Lett. Appl. Microbiol., 19, 110-113 (1994)   DOI   PUBMED   ScienceOn
18 Shahi, S. K., Shukla, A. C., Bajaj, A. K., Medgely, G., and Dikshit, A., Broad spectrum antimycotic drug for the control of fungal infection in human beings. Curr. Sci., 76, 836-839 (1999)
19 Nidiry, E. S., Structure-fungitoxicity relationships of the monoterpenoids of the essential oils of Peppermint (Mentha piperita) and scented geranium (Pelargonium graveolens). J. Essent. Oil Res., 10, 628-632 (1998)   DOI   ScienceOn