Inhibition of COX-2 Activity and Proinflammatory Cytokines() Production by Water-Soluble Sub-Fractionated Parts from Bee (Apis mellifera) Venom |
Nam, Kung-Woo
(Natural Products Research Institute, Seoul National University)
Je, Kang-Hoon (Natural Products Research Institute, Seoul National University) Lee, Jang-Hurn (Department of Veterinary Physiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) Han, Ho-Je (Hormone Research Center, Chonnam National University) Lee, Hye-Jung (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung-Hee University) Kang, Sung-Kil (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung-Hee University) Mar, Woongchon (Natural Products Research Institute & College of Pharmacy, Seoul National University) |
1 | Kwon, Y. B., Lee, J. D., Lee, H. J., Han, H. J., Mar, W., Kang, S. K., Beitz, A. J., and Lee, J. H., Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses. Pain, 90, 271-280 (2001) DOI ScienceOn |
2 | Lin, W. W., Chen, B. C., Hsu, Y. W., Lee, C. M., and Shyue, S. K., Modulation of inducible nitric oxide ynthase induction by prostaglandin E2 in macrophages: distinct susceptibility in murine J774 and RAW 264.7 macrophages. Prostaglandins Other Lipid Mediat., 58, 87-101 (1999) DOI PUBMED ScienceOn |
3 | Mitchell, J. A., Saunders, M., Barnes, P. J., Newton, R., and Belvisi, M. G., Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor B) activation: Role of arachidonic acid. Mol. Pharmacol., 51, 907-912 (1997) DOI PUBMED |
4 | Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63 (1983) DOI PUBMED ScienceOn |
5 | Schagger, H. and von Jagow, G., Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form. Anal. Biochem., 199, 223-231 (1991) DOI ScienceOn |
6 | Warner, T. D., Giuliano, F., Vojnovic, I., Bukasa, A., Mitchell, J. A., and Vane, J. R., Nonsteroid drug selectivities for cyclooxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc. Natl. Acad. Sci. USA, 96, 7563-7568 (1999) DOI ScienceOn |
7 | Zurier, R. B., Mitnick, H., Bloomgarden, D., and Weissmann, G., Effects of bee venom in experimental arthritis. Ann. Rheum. Dis., 32, 466-470 (1973) DOI ScienceOn |
8 | Habermann, E., Bee and wasp venoms. Science, 177, 314-322 (1972) DOI PUBMED |
9 | Creminon, C., Habib, A., Maclouf, J., Pradells, P., Grassi, J., and Frobert, Y., Differential measurement of constitutive (COX-1) and inducible (COX-2) cyclooxygenase expression in human umbilical vein endothelial cells using specific immunometric enzyme immunoassays. Biochim. Biophys. Acta, 1254, 341-348 (1995) DOI PUBMED ScienceOn |
10 | Carteron, N. L., Cytokines in rheumatoid arthritis: trials and tribulations. Mol. Med. Today, 6, 315-323 (2000) DOI PUBMED ScienceOn |
11 | Wadleigh, D. J. and Herschman, H. R., Transcriptional regulation of the cyclooxygenase-2 gene by diverse ligands in murine osteoblasts. Biochem. Biophys. Res. Commun., 264, 865-870 (1999) DOI ScienceOn |
12 | Dinarello, C. A., Role of pro- and anti-inflammatory cytokines during inflammation: experimental and clinical findings. J. Biol. Regul. Homeost. Agents, 11, 91-103 (1997) PUBMED |
13 | Gauldie, J., Hanson, J. M., Rumjan, F. D., Shipolini, R. A., and Vernon, C. A., The peptide components of bee venom. Eur. J. Biochem., 61, 369-376 (1976) DOI ScienceOn |
14 | Simon, L. S., Role and regulation of cyclooxygenase-2 during inflammation. Am. J. Med., 106, 37S-42S (1999) DOI ScienceOn |
15 | Barrios-Rodiles, M., Tiraloche, G., and Chadee, K., Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1 and TNF-. J. Immunol., 163, 963-969 (1999) PUBMED |
16 | Billingham, M. E., Morley, J., Hanson, J. M., Shipolini, R. A., and Vernon, C. A., Letter : An anti-inflammatory peptide from bee venom. Nature, 245, 163-164 (1973) DOI ScienceOn |
17 | OSullivan, M. G., Huggins Jr., E. M., Meade, E. A., DeWitt, D. L., and McCall, C. E., Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages. Biochem. Biophys. Res. Commun., 187, 1123-1127 (1992) DOI ScienceOn |
18 | Hanson, J. M., Morley, J., and Soria, C., Anti-inflammatory property of 401, a peptide from the venom of the bee (Apis mellifica L). Br. J. Pharmacol., 46, 537-538 (1972) |
19 | Liang, Y. C., Huang, Y. T., Tsai, S. H., Lin-Shiau, S. Y., Chen, C. F., and Lin, J. K., Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis, 20, 1945-1952 (1999) DOI ScienceOn |
20 | Shkenderov, S. and Koburova, K., Adolapin-a newly isolated analgetic and anti-inflammatory polypeptide from bee benom. Toxicon., 20, 317-321 (1982) DOI ScienceOn |