[KSCI] Korea Science Citation Index Service

Prevention of Macrophage-Related Inflammatory Diseases by Allergina

Han, Sang-B. (Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Lee, Chang-W. (Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Park, Song-K. (Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Yoon, Won-K. (Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Moon, Jae-S. (Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Lee, Ki-H. (Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Kim, Hyung-C. (Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Kim, Hwan-M. (Korea Research Institute of Bioscience and Biotechnology (KRIBB))

Publication Information

Archives of Pharmacal Research / v.26, no.4, 2003 , pp. 312-316 More about this Journal

Abstract

The oriental herbal combination allergina has been shown to inhibit allergic inflammation. In the present study, we demonstrate that the oral administration of allergina markedly inhibits the progression of inflammatory diseases, such as graft-versus-host diseases (in the allogeneic bone marrow transplantation and the parent-into-F1 transplantation models), collagen-induced arthritis and sheep red blood cell-induced delayed type hypersensitivity. The immunosuppressive activity of allergina in vivo appears to be associated, at least in part, with the inhibition of tumor necrosis factor-a production. In conclusion, our results suggest that allergina could be useful as a immunosuppressive agent for the treatment of macrophage-related inflammatory disease.

Keywords

Allergina; Graft-versus-host diseases; Collagen-induced arthritis; Delayed type hypersensitivity;

Citations & Related Records

Times Cited By Web Of Science : 0 (Related Records In Web of Science)
Times Cited By SCOPUS : 0

Reference

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