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A DNA Strand-Nicking Principle of a Higher Plant, Caesalpinia sappan  

Mar, Woongchon (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Lee, Hyun-Tai (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University)
Je, Kang-Hoon (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Choi, Hye-Young (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University)
Seo, Eun-Kyoung (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University)
Publication Information
Archives of Pharmacal Research / v.26, no.2, 2003 , pp. 147-150 More about this Journal
Abstract
To find anticancer agents from higher plants, DNA strand-scission assay method was employed for bioassay-guided fractionation as well as for screening the crude extracts. During the screening, an ethyl acetate extracts of the heartwood of Caesalpinia sappan L. (Leguminosae) exhibited potent DNA strand-scission activity. Therefore, the ethyl acetate extracts of the dried heartwood of C. sappan was subjected to the bioassay-guided fractionation, which led to the isolation of a known compound, brazilin (1) as the active constituent. In addition, caesalpine J (2) was also isolated as an inactive constituent.
Keywords
DNA strand-scission; Caesalpinia sappan; Brazilin;
Citations & Related Records

Times Cited By Web Of Science : 11  (Related Records In Web of Science)
Times Cited By SCOPUS : 8
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