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Further Isolation of Antioxidative $(+)-1-Hydroxypinoresinol-1-O-{\beta}-D-glucoside$ from the Rhizome of Salvia miltiorrhiza that Acts on Peroxynitrite, Total ROS and 1,1-Diphenyl-2-picrylhydrazyl Radical  

Kang, Hye-Sook (Faculty of Food Science and Biotechnology, Pukyong National University)
Chung, Hae-Young (College of Pharmacy, Pusan National University)
Byun, Dae-Seok (Faculty of Food Science and Biotechnology, Pukyong National University)
Choi, Jae-Sue (Faculty of Food Science and Biotechnology, Pukyong National University)
Publication Information
Archives of Pharmacal Research / v.26, no.1, 2003 , pp. 24-27 More about this Journal
Abstract
A furanofuranoid lignan glycoside, with radical scavenging on peroxynitrite, total reactive oxygen species (ROS) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical, was isolated from the rhizome of Salvia miltiorrhiza and characterized as (+)-1-hydroxypinoresinol-1-Ο-$\beta$-D-glucoside based on spectroscopic evidence. The compound exhibited peroxynitrite, total ROS and DPPH radical scavenging activities with $IC_{50}$ values of 3.23$\pm$0.04, 2.26$\pm$0.07 and 32.3$\pm$0.13 $\mu$M, respectively. Penicillamine, Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) and L-ascorbic acid, acting as positive controls, showed radical scavenging activities with $IC_{50}$ values of 6.72$\pm$0.25, 1.43$\pm$0.04 and 11.4$\pm$0.07 $\mu$M, respectively.
Keywords
Salvia miltiorrhiza; Lignan; Antioxidant; $(+)-1-Hydroxypinoresinol-1-O-{\beta}-D-glucoside$; Peroxynitrite; Total ROS; 1,1-Diphenyl-2-picrylhydrazyl radical;
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