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Synthesis of 5-Chloro-3-[4-(3-diethylaminopropoxy)benzoyl]-2(4-methoxyphenyl)benzofuran as a $\beta-Amyloid$ Aggregation  

Choi, Hong-Dae (Department of Chemistry, Dongeui University)
Seo, Pil-Ja (Department of Chemistry, Dongeui University)
Son, Byeong-Wha (Department of Chemistry, Pukyong National University)
Kang, Byoung-Won (Chemical Biology Institute)
Publication Information
Archives of Pharmacal Research / v.26, no.12, 2003 , pp. 985-989 More about this Journal
Abstract
An efficient synthesis of 5-chloro-3-[4-(3-diethylaminopropoxy)benzoyl]-2-(4-methoxyphenyl)benzofuran (8), a potent $\beta$-amyloid aggregation inhibitor, is described. 5-Chloro-2-(4-methoxyphenyl)benzofuran (3) was obtained by the one-pot synthesis of 4-chlorophenol with $\omega$(methylsulfinyl)-p-methoxyacetophenone (1) under Pummerer reaction conditions, and it was followed by the desulfurization of the resultant 5-chloro-3-methylthio-2-(4-methoxyphenyl)benzofuran (2e). Acylation of benzofuran 3 with 4-(3-bromopropoxy)benzoyl chloride (6) gave the ketone 7, which was converted into compound 8 by the treatment of diethylamine.
Keywords
5-Chloro-3-[4-(3-diethylaminopropoxy)benzoyl]-2-(4-methoxyphenyl)benzofuran; ${\beta}-Amyloid$ aggregation inhibitor; 5-Chloro-2-(4-methoxyphenyl)benzofuran; $\omega$-(Methylsulfinyl)p-methoxyacetophenone; Pummerer reaction conditions; 4-(3-Bromopropoxy)benzoyl chloride;
Citations & Related Records

Times Cited By Web Of Science : 6  (Related Records In Web of Science)
Times Cited By SCOPUS : 7
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