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Synthesis and Antiviral Activity of Novel trans-2,2-Dimethyl Cyclopropyl Nucleosides  

Kook, Min-Chul (College of Pharmacy, Chonnam National University)
Choi, Bo-Gil (College of Pharmacy, Chonnam National University)
Publication Information
Archives of Pharmacal Research / v.26, no.11, 2003 , pp. 887-891 More about this Journal
Abstract
Novel trans-2,2-dimethylcyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate, 3, was synthesized via five steps from ethyl chrysanthemate and condensed with purine bases using the Mitsunobu reaction to give six cyclopropyl nucleosides. These synthesized nucleosides did not show any significant antiviral activity against HSV-1, HSV-2, EMCV, Cox B3, or VSV, at concentrations up to 100 $\mu M$.
Keywords
2,2-Dimethylcyclopropyl nucleoside; Antiviral agent; Ethyl chrysanthemate;
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Times Cited By Web Of Science : 2  (Related Records In Web of Science)
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