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Antimycobacterial and Antioxidant Flavones from Limnophila geoffrayi  

Suksamrarn, Apichart (Department of Chemistry, Faculty of Science, Ramkhamhaeng University)
Poomsing, Ponsuda (Department of Chemistry, Faculty of Science, Ramkhamhaeng University)
Aroonrerk, Nuntana (Department of Stomatology, Faculty of Dentistry, Srinakharinwirot University)
Punjanon, Tadsanee (Department of Medical Sciences, Faculty of Science, Rangsit University)
Suksamrarn, Sunit (Department of Chemistry, Faculty of Science, Srinakharinwirot University)
Kongkun, Somkiat (Department of Chemistry, Faculty of Science, Ramkhamhaeng University)
Publication Information
Archives of Pharmacal Research / v.26, no.10, 2003 , pp. 816-820 More about this Journal
Abstract
The chloroform extract of the aerial part of Limnophila geoffrayi showed antimycobacterial and antioxidant activities. Bioassay-guided fractionation has led to the isolation of the flavones nevadensin (5,7-dihydroxy-6,8,4'-trimethoxyflavone, 1) and isothymusin (6,7-dimethoxy-5,8,4'-trihydroxyflavone, 2). Both compounds 1 and 2 exhibited inhibition activity against Mycobacterium tuberculosis, with equal MIC value of $200{\;}\mu\textrm{g}/mL$. Only compound 2 exhibited antioxidant activity against the radical scavenging ability of DPPH, with the $IC_{50}$ value of $7.7{\;}\mu\textrm{g}/mL$. The crude hexane, chloroform and methanol extracts as well as the pure compounds 1 and 2 did not exhibit mutagenic activity in the Bacillus subtilis recassay.
Keywords
Limnophila geoffrayi; Scrophulariaceae; Flavone; Nevadensin; Isothymusin; Antimycobacterial activity; Antioxidant activity; Mutagenic activity;
Citations & Related Records

Times Cited By Web Of Science : 16  (Related Records In Web of Science)
Times Cited By SCOPUS : 15
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