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Design, Synthesis and Anticonvulsive Activities of Potential Prodrugs Linked by Two-carbon Chain  

Zhao, Long-Xuan (College of Pharmacy, Yeungnam University)
Moon, Yoon-Soo (College of Pharmacy, Yeungnam University)
Basnet, Ar-Jun (College of Pharmacy, Yeungnam University)
Park, Jae-Gyu (College of Pharmacy, Yeungnam University)
Kim, Eun-kyung (College of Pharmacy, Yeungnam University)
Kim, Dae-Ok (College of Pharmacy, Yeungnam University)
Jeong, Tae-Cheon (College of Pharmacy, Yeungnam University)
Jahng, Yurng-Dong (College of Pharmacy, Yeungnam University)
Choi, Jong-Won (College of Pharmacy, Kyungsung University)
Lee, Eung-Seok (College of Pharmacy, Yeungnam University)
Publication Information
Archives of Pharmacal Research / v.26, no.10, 2003 , pp. 785-795 More about this Journal
Abstract
For the development of new anticonvulsive agents, GABAmimetics such as nipecotic acid, isonipecotic acid, ${\gamma}-aminobutyric$ acid (GABA), ${\gamma}-vinyl$ GABA (vigabatrin) and valproic acid were covalently coupled through an ester bond by a two-carbon linker chain as potential prodrugs and evaluated for their anticonvulsive activities.
Keywords
Anticonvulsants; Prodrugs; Synthesis; Linker chain; Anticonvulsive activities;
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