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Acetylcholinesterase Inhibitors from the Roots of Angelica dahurica  

Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Lim, Jong-Pil (College of Pharmacy, Woosuk University)
Yang, Jae-Heon (College of Pharmacy, Woosuk University)
Eom, Dong-Ok (College of Pharmacy, Woosuk University)
Eun, Jae-Soon (College of Pharmacy, Woosuk University)
Leem, Kang-Hyun (College of Pharmacy, Woosuk University)
Publication Information
Archives of Pharmacal Research / v.25, no.6, 2002 , pp. 856-859 More about this Journal
Abstract
In the course of finding Korean natural products for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the roots of Angelica dahurica showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three furanocoumarins, isoimperatorin (1), imperatorin (2) and oxypeucedanin (3), as active principles. These compounds inhibited AChE activity in a dosedependent manner, and the $IC_{50}$ values of compounds 1-3 were 74.6, 63.7 and 89.1 uM, respectively.
Keywords
Angelica dahurica; Anticholinesterase activity; Isoimperatorin; Imperatorin; Oxy-peucedanin;
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Times Cited By Web Of Science : 22  (Related Records In Web of Science)
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