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Inhibitory Effect of Corynoline Isolated from the Aerial Parts of Corydalis incisa on the Acetylcholinesterase  

Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Publication Information
Archives of Pharmacal Research / v.25, no.6, 2002 , pp. 817-819 More about this Journal
Abstract
In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the $IC_{50}$ value of corynoline was $30.6{\;}{\mu}M$. The AChE inhibitory activity of corynoline was reversible and noncompetitive.
Keywords
Corydalis incisa; Papaveraceae; Acetylcholinesterase inhibitor; Corynoline;
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Times Cited By Web Of Science : 8  (Related Records In Web of Science)
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