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Hypocholesterolemic Activity of Bifidobacteria Isolated from a Healthy Korean  

Rhee, Young-Kyung (Department of Food and Nutrition, Kyung Hee University)
Han, Myung-Joo (Department of Food and Nutrition, Kyung Hee University)
Choi, Eung-Chil (College of Pharmacy, Seoul National University)
Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
Publication Information
Archives of Pharmacal Research / v.25, no.5, 2002 , pp. 681-684 More about this Journal
Abstract
This study was undertaken to investigate the hypocholesterolemic activity of Bifidobacteria (B. breve K-110, B. breve K-111, and B. infantis K-525) isolated from a healthy Korean. The administration of B. breve K-110 and K-111 with a high cholesterol diet significantly protected the increase of serum total cholesterol and LDL cholesterol relative to that of a high cholesterol diet alone. Such a diet supplemented with 0.5％ B. breve K-111 decreased serum total cholesterol and LDL cholesterol to 57 and 55％, respectively. The administration of Bifidobacteria also significantly inhibited the lipid-deposited surface in the aorta. The normalizing activity of serum cholesterol level in cholesterolemic rats was accelerated by Bifidobacteria. The normalizing activity of B. breve K-111 on serum cholesterol level was superior to that of B. breve K-110. These results suggest that Bifidobacteria in the human intestine playa role in the prophylactics of arteriosclerosis.
Keywords
Hypercholesterolemia; Bifidobacterium breve K-110; Cholesterol; Lactic acid bacteria;
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Times Cited By Web Of Science : 4  (Related Records In Web of Science)
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1 Perdigon, G., de Jorrat W.E.B., de Petrino, S.F, and Valerde de Budeguer, M., Effect of oral administration of Lactobacillus casei on various biological functions of the host. Food Agric. Immunol., 3, 93-102 (1991)   DOI
2 Taranto, M.P., Medici, M., Perdigon, G., Ruiz Holgado, A.P., and Valdez, G.F., Evidence for hypoglycemic effect of Lactobacillus reuteri in hypercholesterolemic mice. J. Dairy Sci., 81, 2336-2340 (1998)   DOI   PUBMED   ScienceOn
3 Mann, G.V, A factor in yogurt which lowers cholesterolemia in man. Arteriosclerosis, 26, 335-340 (1977)   DOI   PUBMED   ScienceOn
4 Gilliland, S.E., Nelson C.R, and Maxwell C., Assimilation of cholesterol by Lactobacillus acidophilus. Appl. Environ. Microbiol., 49, 377-381 (1985)   PUBMED
5 Ishihara, K., Shin, R., Shiina, T., Yamamoto, H., and Isoda, M., Influence of intestinal bacteria on cholesterol metabolism. In Mitsuoka T.(ed.), Ecology and role of intestinal flora. vol. 9, pp121-144 Japan scientific societies press, Tokyo, (1989)
6 Adachi, S., Lactic acid bacteria and the control of tumors, In Wood, B.J.B. (ed). The Lactic acid bacteria, vol. 1, Elsevier Science Publishers, ltd., Essex, 233-261 (1992)
7 Harrison, V.G., and Peat, G., Serum cholesterol and bowel flora in the newborn. Am. J. Clin. Nutr,. 28,1351-1355 (1975)   PUBMED
8 Rodas, B.Z., Gilliland, S.E., and Maxwell, C.V, Hypocholesterolemic action of Lactobacillus acidophilus ATCC43121 and calcium in swine with hypercholesterolemia induced by diet. J. Dairy Sci., 79, 2121-2128 (1996)   DOI   PUBMED   ScienceOn
9 Reddy, B.S., Mastromarini A, and Wynder, E., Diet and metabolism: large bowel cancer. Cancer, 39, 1815-1819 (1977)   DOI   PUBMED   ScienceOn
10 Han, M.J, Park, H.-Y. and Kim, D.-H., Protective effects of Bifidobacterium spp. on experimental colon carcinogenesis with 1,2-dimethylhydrazine. J. Microbiol. Biotechnol., 9, 368-370 (1999)
11 Salminen, S., Deighton and Gorbach, S., Lactic acid bacteria in health and disease, In Salminen, S. and von Wright, A.(Eds.), Lactic acid bacteria., Marcel Dekker, Inc., New York, 199-226 (1974)
12 Hepner, G., Fried, R., St. Jeor, S., Fusetti, L., and Morin, R., Hypocholesterolemic effect of yogurt and milk. Am. J. Clin. Nutr., 32, 19-24 (1979)   PUBMED
13 Park, H.-Y, Bae, E.-A., Han, M. J. Choi, E.-C. and Kim, D.-H., Inhibitory effects of Bifidobacterium spp. isolated from a healthy Korean on harmful enzymes of human intestinal microflora. Arch. Pharm. Res., 21, 54-61 (1998)   DOI   PUBMED