Metabolism of a New Neuroprotective Agent for Ischemia-Reperfusion Damage, KR-31543 in the Rats using Liquid Chromatography/Electrospray Mass Spectrometry |
Kim, John
(Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Department of Clinical Research, LG Life Sciences, Ltd)
Ji, Hye-Young (Medicinal Resources Research Center and Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University) Lee, Seung-Seok (Medicinal Resources Research Center and Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University) Yoo, Sung-Eun (Korea Research Institute of Chemical Technology) Kim, Sun-Ok (AgroPharma Research Institute, Dongbu Hannong Chemical Company) Lee, Dong-Ha (AgroPharma Research Institute, Dongbu Hannong Chemical Company) Lim, Hong (AgroPharma Research Institute, Dongbu Hannong Chemical Company) Lee, Hye-Suk (Medicinal Resources Research Center and Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, Wonkwang University) |
1 | Yoo, S. E., Yi, K. Y, Lee, S., Suh, J., Kim, N., Lee, B. H., Seo, H. W., Kim, S. O., Lee, D. H., Lim, H. and Shin, H. S., A novel anti-ischemic ATP-sensitive potassium channel opener without vasorelaxation: N-(6-aminobenzopyranyl)-N'-benzyl-N"-cyano-guanidine analogue. J. Med. Chem., 44, 4207-4215 (2001) DOI ScienceOn |
2 | Hong, K.W., Kim, K.Y., Lee, J.H., Shin, H.K., Kwak, Y.G., Kim, S. O., Lim, H. and Yoo, S. E., Neuroprotective effect of (2S,3S,4R)-N'-cyano-N-(6-amino-3, 4-dihydro-3-hydroxy-2methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-ben-zylguanidine (KR-31378), a benzopyran analog, against focal ischemic brain damage in rats. J. Pharmacol. Exp. Ther., 301, 210-216 (2002) DOI ScienceOn |
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